Advances in Traditional Medicine

Kyung Hee Oriental Medicine Research Center (경희대학교 융합한의과학연구소)
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Resibufogenin induces cardiac arrhythmia

  • Xie, Jing-Tian (Tang Center for Herbal Medicine Research,Department of Anesthesia & Critical Care, University of Chicago) ;
  • Mehandale, Sangeeta R. (Tang Center for Herbal Medicine Research,Department of Anesthesia & Critical Care, University of Chicago) ;
  • Malechar, Spring A. (Tang Center for Herbal Medicine Research,Department of Anesthesia & Critical Care, University of Chicago) ;
  • Yuan, Chun-Su (Tang Center for Herbal Medicine Research,Department of Anesthesia & Critical Care, Committee on Clinical Pharmacology, The Pritzker School of Medicine, University of Chicago)
  • Published : 2003.05.30
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Abstract

Resibufogenin is a single compound isolated from the skin venom gland of the toad (Bufo bufo gargarizans cantor). Formulations containing toad venom have been widely used as complementary and alternative medicines. However, like digitalis, resibufogenin possesses both pharmacological and toxicological activities. Our previous data indicated that resibufogenin induces electro-toxicity, including delayed afterdepolarization and triggered arrhythmias at high concentration, both in cardiac fiber in vitro and in beating heart in vivo.

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References

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