Pharmacological study of 'treenoponchomul'-an Ayurvedic diuretic preparation

  • Haque, Sabera (Ethnopharmacology Laboratory, Department of Pharmacy, Jahangirnagar University) ;
  • Hannan, JMA (Department of Pharmacology, Research Division, BIRDEM) ;
  • Shahriar, Masum (Department of Pharmacy, Gono Bishwabidyalay) ;
  • Islam, M Naimul (Ethnopharmacology Laboratory, Department of Pharmacy, Jahangirnagar University) ;
  • Sattar, Mafruhi (Ethnopharmacology Laboratory, Department of Pharmacy, Jahangirnagar University) ;
  • Choudhuri, MSK (Ethnopharmacology Laboratory, Department of Pharmacy, Jahangirnagar University)
  • Published : 2003.02.28


The pharmacological effects of an Ayurvedic diuretic drug 'Treenoponchomul' (TPM) was investigated in animal model. The pharmacological actions of the test drug along with that of the components thereof, on the Central Nervous System (CNS) were studied. The drug under study TPM showed little effect on the CNS, the same can not be said about the components. The most prominent CNS depressant effect was observed with Saccharum officinarum Linn. (EE) in that it lowered the spontaneous motor activity as well the exploratory -behavior of the animals. An exploration retarding effect of moderate degree, was evident with Imperata cylindrica Beauv. (UU), and Phragmites maxima Blatter & McCann (NN). Although the test drug did not alter the normal locomotor and/ or exploratory behavior of the treated animals, it did significantly (p<0.01) lower the locomotion of the amphetamine induced hyperactive animals. TPM along with its components (especially Desmostachya bipinnata Stapf. Root, KU), significantly reduced the gastro-intestinal motility of the treated animals (p<0.01). The test drug and its components lowered the body weight of the treated animals, on being administered chronically (30 days), with EE being the only exception.


  1. Abed L, Benmerabet K. (1981) Significance of Sodium and Potassium in Infusions of Medicinal Plants. Plant Med. Phytother. 15, 92-98.
  2. Agarwal VK. (1979) Pharmacological Studies on Three Grass Roots of Trinapanchamula viz. Saccharum spontaneum Linn., Saccharum munja Roxb. and Phragmites karaka Trin. J.Res. Indian Med. Yoga Homoeopath. 14, 140-144.
  3. Anonymous. (1992) Bangladesh National Formulary of Ayurvedic Medicine Compiled by the National Unani and Ayurvedic Formulary Committee. Bangladesh Board of Unani and Ayurvedic System of Medicine. 116.
  4. Barnes CD, Eltherington LG. (1973) Drug Dosage in Laboratory Animals: A Handbook. 2nd edn, University of California Press-Berkeley.
  5. Bhisagratne KL (Translation). (1963) Susruta Samhita. Chowkhamba Sanskrit Series Office, Varanasi.
  6. Bowman WC, Rand MJ. (1980) Text book of Pharmacology, 2nd edn, p.18.30, Black Well Scientific Publications, New York.
  7. Chatterjee TK. (1993) Handbook on Laboratory Mice and Rats. Department of Pharmaceutical Technology, 1st edn, p.157, Jadavpur University.
  8. Clive DM, Stoff JA. (1984) Renal Syndromes Associated with Non-steroidal Antiinflammatory Drugs. N. Eng. J. Me. 310, 563-572.
  9. Dat DD. (1992) Studies on the Individual and Combined Diuretic Effects of four Vietnamese Traditional Herbal Remedies (Zea mays, Imperata cylindrica, Plantago major and Orthosiphon stamineus). J. Ethnopharmacol. 36, 225-231.
  10. Dev A (Ed.). (1960) Susruta Samhita. 3rd edn. Chowkhamba Sanskrit Series Office, Varanasi.
  11. Glasanapp DR, Poggio JP. (1985) Essentials of Statistical Analysis For the Behavioral Sciences., p.363, Charles E. Merrill Publishing Company, London.
  12. Guyton AC. (1986) Textbook of Medical Physiology, 7th edn, p. 652, W. B. Saunders Company, Philadelphia.
  13. Henrich WL. (1983) Nephrotoxicity of Non-steroidal Antiinflammatory Agents Am. J. Kidney Dis. 11, 478-484.
  14. Hong ND. (1986) Studies on the Efficacy of Combined Preparation of Crude Drugs (XXVIII). Effects of Paeryung-tang and Kamipaeryung-tang on Diuresis, Antipyretic, Antiinflammatory and Analgesic Activity. Korean J. Pharmaocog. 17, 206-214.
  15. Lant AF, Baba WI, Wilson GM. (1966) On the Clinical Evaluation of the Diuretics with Particular Reference to a New Phthalimidine Diuretic Clorexolone. Clin. Pharmacol. Therap. 7, 196-223.
  16. Liverson DJ, Simmons CE Jr, Brenner BM. (1982) Arachidonic Acid Metabolism, Prostaglandins and the Kidney. Am. J Med. 72, 354-374.
  17. Peck C, Wallace M. (1980) Problems in Pain, p. 24, McGraw-Hill Book Company Inc., New York.
  18. Robbins TW. (1977) A Critique of the Methods Available for the Measurement of Spontaneous Motor Activity. In: Handbook of Pscychopharmacology, Iversen LL, Iversen SD and Snyder SH (Eds.), p. 37, Plenum Press, New York.
  19. Sandberg F. (1959) A Comparative Quantitative Study of the Central Depressant Effect on Seven Clinically Used Phenothiazine Derivatives, Arzneimittel. Forsch. 203-206.
  20. Siegmund PN. (1952) Displacement of Sand Method for the Determination of Locomotor Activity. Arch. Exp. Patho.l Pharmacol. 216, 232-235.
  21. Singh LM, Sachan SS. (1979) Management of Urolithiasis by Indigenous drugs. J. Nepal. Pharmaceut. Assoc. 7, 81-85.
  22. Takagi K, Watanbe M , Saito H. (1971) Studies of the Spontaneous Movement - of Animals by the Hole Cross Test: Effect of 2-dimethylminoethanol and Its Acylesters on the Central Nervous System. Jap. J. Pharmacol. 21, 797-810.
  23. Tedeschi DW, Tedeschi RE. (1968) Importance of Fundamental Principles of Drug Evaluation. p. 307, Raven Press, New York.
  24. Woolfe G , Macdonald AD. (1944) The Evaluation of the Analgesic Action of Pethidine Hydrochloride (Demerol). J. Pharmacol. Exp. Ther. 80, 300-307.
  25. Vane JR. (1961) Tryptamine Receptors in the Central Nervous System. Nature. 191, 1068-1069.