Journal of Pharmaceutical Investigation

The Korean Society of Pharmaceutical Sciences and Technology (한국약제학회)
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Design of Transdermal Delivery System Using New Film-Forming Agents

신규 필름형성제를 이용한 경피흡수제제의 설계

  • 최양규 (태평양기술연구원 의약건강연구소) ;
  • 김영소 (태평양기술연구원 의약건강연구소) ;
  • 김정주 (태평양기술연구원 의약건강연구소) ;
  • 심영철 (태평양기술연구원 의약건강연구소)
  • Published : 2003.09.20
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Abstract

In order to develop a film-forming transdermal drug delivery system, polyurethane (PU) based on poly(ethylene glycol) and poly(tetramethylene oxide) was synthesized and characterized. The synthesized PU was blended with Gantrez ES 225 (GT) to improve the adhesion property of film-forming agent to the skin. When film-forming gel formulation containing 3% ketoprofen (KP) was applied, transparent thin film was obtained within 5 minutes and adhered to the skin for 8 hours. In vitro percutaneous absortion studies were performed to determine the rate of ketoprofen absorption through guinea pig skin. A prominent effect of limonene on the skin permeability of ketoprofen was observed among the various skin permeation enhancers investigated. Considering mechanica properties of film and skin permeability of ketoprofen, 2% of limonene was optimal content in the film forming transdermal formulation.

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References

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