Journal of Pharmaceutical Investigation

  • 제33권2호
  • /
  • Pages.121-127
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  • 2003
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  • 2093-5552(pISSN)
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  • 2093-6214(eISSN)
한국약제학회 (The Korean Society of Pharmaceutical Sciences and Technology)
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심바스타틴 자가유화약물전달시스템의 마이크로캡슐화를 통한 고형제제의 개발

Preparation of Solid Dosage Form containing SMEDDS of Simvastatin by Microencapsulation

  • 강복기 (전북대학교 고분자공학과) ;
  • 윤복영 (전북대학교 고분자공학과) ;
  • 서광수 (전북대학교 고분자공학과) ;
  • 정상영 (한국화학연구원 생체의료고분자팀) ;
  • 길희주 (한남대학교 고분자공학과) ;
  • 강길선 (전북대학교 고분자공학과) ;
  • 이해방 (한국화학연구원 생체의료고분자팀) ;
  • 조선행 (한국화학연구원 생체의료고분자팀)
  • Kang, Bok-Ki (Department of Polymer Science and Technology, Chonbuk National University) ;
  • Yoon, Bok-Young (Department of Polymer Science and Technology, Chonbuk National University) ;
  • Seo, Kwang-Su (Department of Polymer Science and Technology, Chonbuk National University) ;
  • Jeung, Sang-Young (Biomaterials Laboratory, Korea Research Institute of Chemical Technology) ;
  • Kil, Hee-Joo (Department of Macromolecular Science, Hannam University) ;
  • Khang, Gil-Son (Department of Polymer Science and Technology, Chonbuk National University) ;
  • Lee, Hai-Bang (Biomaterials Laboratory, Korea Research Institute of Chemical Technology) ;
  • Cho, Sun-Hang (Biomaterials Laboratory, Korea Research Institute of Chemical Technology)
  • 발행 : 2003.06.20
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초록

The objective of this study was to solidify the simvastatin self-microemulsifying drug delivery system (SMEDDS) and to improve the encapsulation efficiency of solidified alginate beads using sodium alginate. Typical simvastatin SMEDDS was composed of various oils, surfactants and cosurfactants. Also solidified-alginate beads was prepared by crosslinking liquid emulsion mixtures containing sodium alginate and other excipients (cetylpyridinum chloride (CP-Cl), hydroxypropyl methylcellulose, starch and so on). in $CaCl_2$ solution, it has been investigated that the drug release pattern and encapsulation efficiency were varied with the ratio of cationic lipid (CP-Cl). Solidified sodium alginate beads containing simvastatin SMEDDS were redispersed into media without re-aggregation. Oil droplet size of redispersed solidified-beads in media produced smaller than the initial size. The density of beads and drug loading amount were increased with increasing cationic lipid content. These systems have advantages of storage stability and predictability of drug release rate.

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