Korean Journal of Oriental Medicine (한국한의학연구원논문집)
- Volume 9 Issue 1
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- Pages.137-144
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- 2003
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- 1229-3377(pISSN)
Studies on medicinal protection with KH-19 against side effect of 5-fIurouracil and its mechanism
KH-19의 5-flurouracil 부작용 억제 효력 및 기전 연구
- Yang, Dong-Sik (Korea Institute of Oriental Medicine) ;
- Sung, Hyun-Jea (College of Oriental Medicine, Semyung University) ;
- Yoon, Yoo-Sik (Korea Institute of Oriental Medicine)
- Published : 2003.06.30
Abstract
The objective on this study was to investigate medicinal protection with KH-19, which was composed of 9 kinds of oriental herbs tonifying the blood, against side effect of chemotherapy in mice and its mechanism through microarray. Not only WBC (white blood cell), and PLT (platelet) as a hematopoiesis toxicity indicator but also spleen weight as an immune toxicity indicator was reduced significantly 7 day after. 5-flurouracil (FU) treatment. However, reduction of WBC, PLT, and spleen weight after 5-FU treatment was significantly recovered by KH-19. For mechanic study on KH-19 action, gene expression in mouse spleen treated 5-FU was compared with gene expression in mouse treated 5-FU and KH-19. The result indicates that 23 genes were increased. in expression level over 2 fold and 41 genes were decreased in expression level more than 2 fold at mouse spleen by KH-19 treatment. KH-19 mechanism may be complicated more than other drug which of mechanism were composed of single compound because KH-19 was composed of various compounds.