Journal of the Korean Society of Food Culture (한국식생활문화학회지)

Korean Society of Food Culture (한국식생활문화학회)
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Effects of Extracts of Shanshuyu(Cornus officinalis sieb) on Removal of Lead in Rat

산수유 추출물의 납 제거 효과에 미치는 영향

  • Shin, Mee-Kyung (Dept. of Food of Nutrition, College of Human Environmental Science, Wonkwang University) ;
  • Lee, Sang-Bok (National Honam Agr. Experiment St. RDA) ;
  • Han, Sung-Hee (Dept. of Food of Nutrition Wonkwang Health Science College)
  • 신미경 (원광대학교 생활과학 대학식품영양학과) ;
  • 이상복 (농촌진흥청 호남농업시험장 전작과 재배생리연구실) ;
  • 한성희 (원광보건대학 식품영양과)
  • Published : 2003.12.30
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Abstract

This study was designed to investigate the effects of Korean 1% Shanshuyu extract in Pb administered rats. Forty male Sprague-Dawley rats weighed 100 l0g were used for this experiment and divided into following 4 groups; Con(control group), Shan(1% Shanshuyu extract), Pb(1,000ppm alone lead administered group), Pb-Shan(1,000ppm alone lead administered group with 1% Shanshuyu extract group). Food intake weight and FER(Food efficiency ratio) were remarkably decreased in lead added group. Tissue weight of liver, lung, stomach, heart, kidney and spleen of lead exposed rats were reduced by 1% Shanshuyu extract group. The lead content in the rats tissue of lead alone administered group was lower than in the rats tissue of lead administered group with 1% Shanshuyu extract group. AST(Asparatate transferase) and ALT(Alanine transferase) were increased in lead-administered group and lower in the 1% Shanshuyu extract group. These results suggested that 1% Shanshuyu extract may have some protective effects from of tissue demage induce with Lead.

납과 산수유 열수 추출물을 6주간 급여하여 사육한 흰쥐의 식이섭취량, 음용수 섭취량, 체중증가량과 식이효율에서 흰쥐의 평균 체중 증가량과 식이섭취량은 정상군에 비하여 납 단독 급여군이 낮은 증가를 보였다. 간 장기 조직의 중량은 납 단독 급여군이 정상군에 비하여 증가하였다. 납 해독에 미치는 영향은 각 장기 조직에서 정상군과 산수유 급여군은 납 단독 급여군에 비하여 유의적으로 낮은 증가를 보였다. 반면에 납과 산수유 병합급여군은 정상군에 가깝게 회복되어 산수유가 어느 정도 조직을 보호하는 것으로 생각된다. 혈청 중의 AST와 ALT 활성은 정상군에 비하여 납 단독 투여군이 유의적으로 증가되었으며, 산수유 추출물 급여군은 억제되었다.

Keywords

References

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