Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Hypoglycemic Activity of Opuntia ficus-indica var.sabotan on Alloxan- or Streptozotocin-Induced Diabetic Mice

Alloxan 및 Streptozotocin 유도 당뇨모델 동물에서 손바닥 선인장의 혈당강하 효과

  • Published : 2003.03.30
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Abstract

Hypoglycemic activity of Opuntia ficus-indica var. sabotan on alloxan or streptozotocin-induced diabetic mice was investigated. Fructus and folium of Opuntia ficus-indica vars. sabotan inhibited intestinal ${\alpha}-glucosidase$ of rats as well as glucose elevation in blood of normal mice, Opuntia ficus-indica var. sabotan exhibited inhibitory activities on streptozotocin-induced diabetic mice rather than on alloxan-induced diabetic mice loaded with maltose and sucrose. Its folium was more effective than its fructus. These results suggest that Opuntia ficus-indica var. sabotan might be effective on diabetic mellitus.

Alloxan 및 streptozotocin 유도 당뇨모델 동물에서 손바닥 선인장 (Opuntia ficus-indica fructus)의 혈당강하효과를 조사하였다. 손바닥 선인장의 열매와 잎은 in vitro에서 흰쥐의 소장 ${\alpha}-glucosidase$를 농도의존적으로 저해하였다. 손바닥 선인장의 열매와 잎으로 정상 생쥐와 streptozotocin으로 유도한 당뇨 모델 생쥐에서 Opuntia ficus-indica의 혈당강하 효과를 조사한 결과 maltose, sucrose 부하에 의한 혈당 상승을 농도 의존적으로 유의하게 억제하였다. 그러나 alloxan 유도 당뇨모델 동물에서는 혈당강하효과가 약하였다. 아울러 이 손바닥 선인장 잎과 열매는 정상 생쥐에서도 혈당강하효과를 나타냈다. 이러한 결과로 볼 때 손바닥 선인장은 인슐린 의존형인 제 1형 당뇨에 효과가 있을 것으로 사료된다.

Keywords

References

  1. Noel, D.V. (1986) Lesser-known plants of potential use in agriculture and forestry. Science. 232: 1379 https://doi.org/10.1126/science.232.4756.1379
  2. Sawaya, W.N. and Khatchandourian, H.A. (1983) Chemical characterizationof prickly pear, Opuntia ficus-indica, and the manufacturing of pricly peart jam. Presented at the 68th Annual meeting of the intemational of milk, food & enviroment sanitarians, Inc. Spokane, WA, Aug. 9012
  3. Lee, Y.C., Hwang, K.H., Han, D.H. and Kim, S.D. (1997) Compositions of Opuntia ficus-indica. Kor. J Food Sci. Technol. 29(5): 847-853
  4. http://www.bukjeju.agri.cheju.kr/totallgoodiOOl.htm
  5. http://members.tripod.co.kr/orange72/sub-2.
  6. Shin, J.E., Han, M.J., Lee, Y.C,, Moon, Y.I. and Kim, D.H. (2002) Antidiabeticactivity of Opuntia ficus-indica var. sabotan on db/db mice. Kor. J. Pharmacol., 33(4): 332-336
  7. Nam, M.S., Kim, K.R., Cho, J.H., Lee, K.M., Park, H.Y., Lee, E.J., Lim, S.K., Lee, H.C. and Huh, KB. (1994) A study on the folk remedies by the questionnaries in Korean diabetic patients. Diabetes. 18(3): 242-248
  8. Hikino, H., Mizuno, T., Oshima, Y. and Konno, C. (1985) Isolation. and hypoglycemic acticity of Moran A, a glycoprotein of Moms Alba Root Barks. Planta Medica. 159-162
  9. Kimura, M., Chen, F.J., Nakashima, N., Kimura, I., Asano, N. and Koya, S. (1995) Antihyperglycemic effects of Ncontaining sugars derived from Mulberry leaves in streptozotocininduced diabetic mice. J. Traditional Medicines. 12: 214-219
  10. Ahmed, A.E., Smithard, R. and Ellis, M. (1991) Activities of enzymes of the pancrease, and the lumen and mucosa of the small intestine in growing broiler cockerels fed on tannincontaining diets. Br. J. Nutr. 65: 189-197 https://doi.org/10.1079/BJN19910080
  11. Lee, S.P., Whang, K and Ha, Y.D. (1998) Functional properties of mucilage and pigment extracted from Opuntia Ficus-indica. Kor. Soc. Food Sci. Nutr. 7: 822-826
  12. Kim, I.H., Kim, M.H., Kim, H.M. and Kim, Y.E. (1995) Effect of antioxidants on the thermostability of red pigment in prickly pear. Kor. J. Food Sci. Thechnol. 27: 1013-1016
  13. Chung, M.S. and Kim, KH. (1996) Stability of betanine extracted from Opuntia Ficus-indica var. Saboten. Kor. J Soc. Food Sci. 12: 506-510
  14. Malaisse, W. J, Malaisse-Lagae, F., Sener,A and Pipeleers, D.G. (1982) Determinants of the selective toxicity of alloxan on the pancreatic $\beta$-cell. Proc. Natl. Aoad. Sci. 79: 927-930 https://doi.org/10.1073/pnas.79.3.927
  15. Axelrad, A.D., Lawrence, A.L. and Hazelwood, R.L. (1970) Fasting and alloxan diabetes effects on intestinal transport of monosaccharides. Am J. Physiol. 21 : 860-864