Natural Product Sciences

  • 제9권4호
  • /
  • Pages.270-272
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  • 2003
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  • 1226-3907(pISSN)
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  • 2288-9027(eISSN)
한국생약학회 (The Korean Society of Pharmacognosy)
권호 표지

Constituents of Euphorbia milii

  • YunChoi, Hye-Sook (Natural Products Research Institute, Seoul National University) ;
  • Jin, Jing-Ling (Natural Products Research Institute, Seoul National University) ;
  • Hong, Sung-Won (Natural Products Research Institute, Seoul National University) ;
  • Lee, Yong-Yook (Natural Products Research Institute, Seoul National University) ;
  • Lee, Jo-Hyung (Natural Products Research Institute, Seoul National University)
  • 발행 : 2003.12.01
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초록

The methanol extract of Euphorbia milii exhibited strong inhibitory effect on platelet aggregation in the cource of our search for anti-platelet component from succulent plants. Two components, components 1 and 2 were isolated from this plant. 1 was the mixture of 72% of 1-octacosanol (1a) and 28% of 1-triacontanol (1b), and 2 was identified as ${\beta}-sitosterol$. 2 ($IC_{50}$: $195\;{\mu}M$, and $170\;{\mu}M$ respectively) was about two fold stronger than ASA ($IC_{50}$: $420\;{\mu}M$ and $340\;{\mu}M$ respectively) on both collagen and U46619 induced aggregation, while the effect of 1 to platelets was negligible.

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참고문헌

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