Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
권호 표지

Superoxide and Hydrogen Peroxide Scavenging Action of Ocimum Sanctum Extracts and their Fractions

  • Geetha, S. (University Grant Commission Teacher Research Fellow, Department of Biochemistry, Kasturba Medical College, MAHE) ;
  • Kedlaya, R. (Department of Biochemistry, Kasturba Medical College, MAHE) ;
  • Vasudevan, D.M. (Principal, Amrita Institute of Medical Sciences and Research Center)
  • Published : 2003.12.01
Download PDF
⟨ Previous Next ⟩

Abstract

Ocimum sanctum, the Indian holy basil has significant abilities to scavenge highly reactive free radicals. Shade dried leaf powder of plant has extracted with water and alcohol, fractionated with different solvents. Both extracts and their fractions were found to be good scavengers of Superoxide and hydrogen peroxide. Free radical scavenging action of these compared with ascorbic acid, a known antioxidant.

Keywords

References

  1. Alho, H., Leinonen, J, Methods in Enzymology, Academic press, New York. 299, 3 (1999)
  2. Ganasoundari, A., Uma Devi, P. and Rao, M.N.A., Protection against radiation-induced chromosome damage in mouse bone marrow by Ocimum sanctum. Mutat Res, 373,271 (1997) https://doi.org/10.1016/S0027-5107(96)00208-4
  3. Ganasoundari, A., Uma Devi, P and Rao, B.S.S., Enhancement of bonemarrrow radiation protection and reduction in WR-2721 toxicity by Ocimum sanctum. Mutat Res, 397, 303 (1998) https://doi.org/10.1016/S0027-5107(97)00230-3
  4. Liu, E, Ooi, V.E.C., Chang, T., Free radical scavenging activities of mushroom polysaccharide extracts. Life Sciences, 60(10), 763-771(1997) https://doi.org/10.1016/S0024-3205(97)00004-0
  5. Narla, R. S., Rao, M.N.A., Scavenging of Free-radicals and Inhibition of Lipid Peroxidation by 3-Phenylsydnone. J. Pharm. Phannacol. 47,623-624 (1995)
  6. Paya, M., Halliwell. B., Hoult, J.R.S., Intraction of a series of coumarins with reactive oxygen species. Scavenging of Superoxide, hydrochlorous acid and hydroxyl radicals. Biochem Phannacol, 44, 205 (1992) https://doi.org/10.1016/0006-2952(92)90002-Z
  7. Satyavathi, G. V, Gupta, K. A., Tandon, N., (eds.), Medicinal Plants of India, ICMR New Delhi. 2, 354 (1987)
  8. Shimoi, K., Masuda, S., Shen, B., Furugori, M., Kinae, N., Radioprotective effect of antioxidative plant Flavonoids in mice. Mutat. Res. 350, 153-161 (1996) https://doi.org/10.1016/0027-5107(95)00116-6
  9. Skaltsa, H., Tzakou, O., Singh, M., Polyphenols of Ocimum sanctum from Suriname. Pharmaceutical Biol. 37(1), 92-94 (1999) https://doi.org/10.1076/phbi.37.1.92.6318
  10. Suffness, M., Douros.J, Methods in cancer Research, De Vita, V.T., Busch, H., (eds.) Academic Press New York. 116,79-83 (1979)
  11. Uma Devi, P and Ganasoundari, A., Radioprotective effect of leaf extract of Indian medicinal plant Ocimum sanctum. Indian J Exp Biol, 33, 205 (1995)
  12. Uma Devi, P. and Ganasoundari, A., Modulation of glutathione and antioxidant enzymes by Ocimum sanctum and its role in protection against radiation injury. Indian J Exp Biol, 37, 262, (1999)
  13. Uma devi, P, Ganasoundari, A., Vrinda, B., Srinivasan, K.K. and Unnikrishnan, M. K., Radiation protection by the Ocimum Flavonoids orientin and vicenin mechanisms of Action. Radiat Res, 154, 455 (2000) https://doi.org/10.1667/0033-7587(2000)154[0455:RPBTOF]2.0.CO;2
  14. Weiss, J. F, Landauer, M. R., Radioprotection by Antioxidants. Ann. N. .Y Acad. Sci. 899,44-55 (2000) https://doi.org/10.1111/j.1749-6632.2000.tb06175.x