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The Korean Society of Pharmacognosy (한국생약학회)
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Ethnopharmacological Evaluation of Peristrophe bicalyculata Nees. for Anti-inflammatory and Analgesic Activity

  • Rathi, Anshu (Pharmacognosy and Ethnopharmacology Division National Botanical Research Institute, (Council of Scientific Industrial Research)) ;
  • Rao, Ch.V. (Pharmacognosy and Ethnopharmacology Division National Botanical Research Institute, (Council of Scientific Industrial Research)) ;
  • Khatoon, S. (Pharmacognosy and Ethnopharmacology Division National Botanical Research Institute, (Council of Scientific Industrial Research)) ;
  • Mehrotra, S. (Pharmacognosy and Ethnopharmacology Division National Botanical Research Institute, (Council of Scientific Industrial Research))
  • Published : 2003.09.01
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Abstract

The ethanolic (50% v/v) extracts of Peristrophe bicalyculata Nees. (Acanthaceae) were examined for anti-inflammatory and analgesic activities in experimental animals. P. bicalyculata in doses of 50, 100 and 200 mg/kg caused a dose dependent inhibition of swelling caused by carrageenin equivalent to 12.25-24.49% protection and 16.62-39.44% in cotton pellet induced granuloma in rats. There was a significant increase in the tail-flick reaction time in mice (18.05-76.43% protection) and analgesy-meter induced pain in rats (14.49-56.85%) protection). The extract of P. bicalyculata resulted in an inhibition of stretching episodes and the protection range of 14.49-56.85% respectively in acetic acid induced writhing.

Keywords

References

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