Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Antioxidant Activities of Decursinol Angelate and Decursin from Angelica gigas Roots

  • Lee, Sang-Hyun (Natural Products Research Institute, Seoul National University,College of Pharmacy, Seoul National University) ;
  • Lee, Yeon-Sil (Natural Products Research Institute, Seoul National University) ;
  • Jung, Sang-Hoon (Natural Products Research Institute, Seoul National University) ;
  • Shin, Kuk-Hyun (Natural Products Research Institute, Seoul National University) ;
  • Kim, Bak-Kwang (College of Pharmacy, Seoul National University) ;
  • Kang, Sam-Sik (Natural Products Research Institute, Seoul National University,College of Pharmacy, Seoul National University)
  • Published : 2003.09.01
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Abstract

The anti-oxidant activities of decursinol angelate (1) and decursin (2) isolated from Angelica gigas were investigated. These two coumarins exhibited decrease in serum transaminase activities elevated by hepatic damage induced by $CCl_4-intoxication$ in rats. They also showed increase in anti-oxidant enzyme such as hepatic cytosolic superoxide dismutase (SOD), catalase, and glutathione peroxidase (GSH-px) in $CCl_4-intoxicated$ rats. These results suggest that decursinol angelate (1) and decursin (2) from A. gigas possess not only the anti-oxidant, but also the hepatoprotective activities in rats.

Keywords

References

  1. Beckman, K. B., and Ames, B. N., The free radical theory of aging matures. Physiol. Rev. 78,547-581 (1998)
  2. Burk, R. F., Nishiki, K, Lawrence, R A., and Chance, B., Peroxide removal by selenium dependent and selenium independent glutathione peroxidases in hemoglobin free perfused rat liver. J. Biol. Chem. 253,43-46 (1978)
  3. Cerutti, P. A., Oxidant stress and carcinogenesis. Eur. J. Clin. Invest. 21, 1-11 (1991) https://doi.org/10.1111/j.1365-2362.1991.tb01350.x
  4. Chi, H.J., and Kim, H. S., Studies on essential oils of plants of Angelica genus in Korea (I) Essential oils of Angelicae gigantis Radix. Kor. J. Phannacogn. 19, 239-247 (1988)
  5. Chi, H.-J., Studies on the components of Umbelliferous plants in Korea (IV). Yakhak Hoeji 13, 47-50 (1969)
  6. Choi, Y. E., Ahn, H., and Ryu, J.-H., Polyacetylenes from Angelica gigas and their inhibitory activity on nitric oxide synthesis in activated macrophages. Biol. Phann. Bull. 23, 884-886 (2000) https://doi.org/10.1248/bpb.23.884
  7. Cross, C. E., Oxygen radicals and human disease. Ann. Intern. Med. 107, 526-545 (1987) https://doi.org/10.7326/0003-4819-107-4-526
  8. Jung, D. J., Porzel, A., and Huneck, S., Gigasol and other coumarins from Angelica gigas. Phytochem. 30,710-712 (1991) https://doi.org/10.1016/0031-9422(91)83763-B
  9. Kang, S. Y., Lee, K. Y., Sung, S. H., Park, M. J., and Kim, Y.C., Coumarins isolated from Angelica gigas inhibit acetyl cholinesterase: structure activity relationships. J. Nat. Prod. 64, 683-685 (2001) https://doi.org/10.1021/np000441w
  10. Kim, H.S., Park, J.S., Park, H.J., and Chi, H.J., A study of the effects of the root components of Angelica gigas Nakai on voluntary activity in mice. Kor. J. Pharmacogn. 11, 11-14 (1980)
  11. Konoshima, M., Chi, H.-J., and Hata, K, Coumarins from the root of Angelica gigas Nakai. Chem. Phann. Bull. 16, 1139-1140 (1968) https://doi.org/10.1248/cpb.16.1139
  12. Kumaravelu, P.,Dakshinamoorthy, D.P., Subramaniam, S., Devaraj, H., and Devaraj, N.S., Effect of eugenol on drug metabolizing enzymes of carbon tetrachloride intoxicated rat liver. Biochem. Phannacol. 49, 1703-1707 (1995) https://doi.org/10.1016/0006-2952(95)00083-C
  13. Lee, S., Kang, S. S., Shin, K. H., Coumarins and a pyrimidine from Angelica gigas roots. Nat. Prod. Sci. 8, 58-61 (2002)
  14. Lowry, O. H., Posenbrough, N. N., Farr, A. L., and Randall, R J., Protein measurement with the folin phenol reagent. J. Biol. Chem. 193, 265-275 (1951)
  15. McCord, J. M., and Fridovich, I., Superoxide dismutase: An enzymatic function for erythrocuprein (hemocoprein). J. Biol. Chem. 244, 6049-6055 (1969)
  16. Pachaly, P., Treitner, A., and Sin, K. S., Neue Cumaringlykoside aus Angelica gigas. Phannazie 51, 57-61 (1996)
  17. Pike, J., and Chandra, R K, Effect of vitamin and trace element supplementation on immune indices in healthy elderly. Int. J. Vitamin Nutr. Res. 65, 117-120 (1995)
  18. Recknagel, R O., Glende Jr., E. A., Dolak, J. A., and Waller, R L., Mechanisms of carbon tetrachloride toxicity. Phannacol' Therapeut. 43, 139-154 (1989) https://doi.org/10.1016/0163-7258(89)90050-8
  19. Reitman, S., and Frankel, S., A chlorotrimetric method for the determination of sGOT and sGPT. Am. J. Clin. Pathol' 28, 56-63 (1957)
  20. Rigo, A., and Rotilio, G., Simultaneous determination of superoxide dismutase and catalase in biological materials by polarography. Anal. Biochem. 81, 157-166 (1977) https://doi.org/10.1016/0003-2697(77)90609-1
  21. Ryu, K. S., Hong, N. D., Kim, N. J., and Kong, Y. Y., Studies on the coumarin constituents of the root of Angelica gigas Nakai. Isolation of decursinol angelate and assay of decursinol angelate and decursin. Kor. J. Phannacogn. 21, 64-68 (1990)
  22. Shin, K. H., Han, J. M., and Lee, I. R, Effect of the constituents of Angelicae gigantis radixon hepatic drug metabolizing enzymes. Kor. J. Phannacogn. 27, 323-327 (1996)
  23. Yook, C. S., Coloured medicinal plants of Korea, Academy Book Co., Seoul, 1990, p. 390