Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Inhibitory Effect of Ginseng Polyacetylenes on Infection and Vacuolation of Helicobacter pylori

  • Kim, Jong-Mi (College of Pharmacy, Kyung Hee University) ;
  • Shin, Ji-Eun (Department of Food and Nutrition, Kyung Hee University) ;
  • Han, Myung-Joo (Department of Food and Nutrition, Kyung Hee University) ;
  • Baek, Nam-In (Department of Oriental Medicinal Materials and Processing, Kyung Hee University) ;
  • Kim, Dong-Hyun (College of Pharmacy, Kyung Hee University)
  • Published : 2003.09.01
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Abstract

Polyacetylenes were isolated from Panax ginseng C.A. Meyer (Family Araliaceae), and their inhibitory effects on growth, infection and VacA vacuolation of Helicobacter pylori (HP) were investigated. Ginseng polyacetylenes did not inhibit the infection of HP into KATO cells. However, polyacetylenes inhibited HP growth and vacuolation of Hela by VacA toxin. Panaxytriol showed the most potent inhibition with $IC_{50}$ values of 0.05 and 0.046 mg/ml, respectively.

Keywords

References

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