Natural Product Sciences

  • 제9권2호
  • /
  • Pages.97-101
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  • 2003
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  • 1226-3907(pISSN)
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  • 2288-9027(eISSN)
한국생약학회 (The Korean Society of Pharmacognosy)
권호 표지

Sulfuretin, an Antinociceptive and Antiinflammatory Flavonoid from Rhus verniciflua

  • 발행 : 2003.06.01
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초록

This study was undertaken to evaluate the antinociceptive and antiinflammatory effects of the heartwood extract of Rhus verniciflua (Anacardiaceae) and the two major components, sulfuretin and fustin. The MeOH extract, its EtOAc-soluble portion and sulfuretin showed significant antinociceptive activity in writhing and hot plate test assays and antiinflammaory effects in carrageenan-induced hind paw edema in rats. In particular, treatment of sulfuretin with 10 mg/kg dose (i.p.) reduced writhing frequency by 48.0% (p<0.01) compared to that of a control group. Further, the treatment of sulfuretin (5, 10 mg/kg, i.p.) for 7 days prevented the carrageenan-induced hind paw edema significantly (p<0.01). The antiinflammatory effect of sulfuretin was also confirmed by microscopic observation of mast cell numbers in muscle. In addition, sulfuretin suppressed the cyclooxygenase- 2 (COX-2) activity $(IC_{50}\;=\;28.7\;{\mu}M)$ in lipopolysaccharide-activated macrophage cells. This result indicates that the inhibitory effect of sulfuretin on COX-2 may be one of the antinociceptive/antiinflammatory mechanism.

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참고문헌

  1. Crunkhom P., Meacock S. C., Mediators of the inflammation induced in rat paw by carrageenin, British Joumal of Pharmacology, 42, 392-402 (1971) https://doi.org/10.1111/j.1476-5381.1971.tb07124.x
  2. Harbome, J. B., Dictionary of Natural Products Vol. 10. Chapman & Hall, New York, p. 5716 (1994a)
  3. Harbome, J. B.,.Dictionary of Natural Products Vol. 9. Chapman & Hall, New York, p. 5455 (1994b)
  4. Hirota, S., Matsumoto, H., Sakurai, T.,Kitagawa, T., Yamaguchi, O., Observation of Cu-$N_3$-stretching bands for mono-axide adduct of Rhus vernicifera laccase. Biochemical and Biophysical Research Communication, 243, 435-437 (1998) https://doi.org/10.1006/bbrc.1998.8108
  5. Kim, M. J., Kim, G. T., Choi, T. B., Hyun, J. O., Effects of climatic factors and tapping date on yield and quality of lactree (Rhus verniciflua) sap. Korean Journal of Plant Resources, 11,70-79 (1998)
  6. Lewis, A. J., Nelson, D. J., Sugrue, M. F., 1975. On the ability of prostaglandin E1, and arachidonic acid to modulate experimentally induced oedema in the rat paw, British Journal of Pharmacology, 55, 51-56 (1975) https://doi.org/10.1111/j.1476-5381.1975.tb07609.x
  7. Miller, W. C., Thielman, N. M., Swai, N., Cegielski, J. P., Shao, J., Ting, D., Mlalasi J., Manyenga D., Lallinger, G. J., Delayed type hypersensitivity testing in Tanzanian adults with HIV infection. Joumal of Acquired Immune Deficiency, 12, 303-308 (1996)
  8. Moncada, S,. Ferreira, S. H., Vane, J. R., Inhibition of prostaglandin biosynthesis as the mechanism of analgesia of aspirin-like drugs in dog knee joint, European Journal of Pharmacology, 31, 250-260 (1975) https://doi.org/10.1016/0014-2999(75)90047-3
  9. Whittle, B. A., The use of change in capillary permeability to distinguish between narcotic and anagesic. British Journal of Pharmacology, 22, 246-460 (1949)