Journal of Oriental Neuropsychiatry (동의신경정신과학회지)

The Korean Society of Oriental Neuropsychiatry (대한한방신경정신과학회)
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Study on the Memory Enhancement of the Extract of Gongjadaesungjichimjung-bang(GDJB)

공자대성지침중방(孔子大聖智枕中方)의 기억증진(記憶增進) 효과(效果)에 관(關)한 실험적(實驗的) 연구(硏究)

  • Kang, Yeon-Sug (Dept. of Neuropsychiatry, College of Oriental Medicine Dong Guk University) ;
  • Chang, Mi-Kyung (Dept. of Neuropsychiatry, College of Oriental Medicine Dong Guk University) ;
  • Kim, Geun-Woo (Dept. of Neuropsychiatry, College of Oriental Medicine Dong Guk University) ;
  • Koo, Byung-Soo (Dept. of Neuropsychiatry, College of Oriental Medicine Dong Guk University)
  • 강연숙 (동국대학교 한의과대학 신경정신과학교실) ;
  • 장미경 (동국대학교 한의과대학 신경정신과학교실) ;
  • 김근우 (동국대학교 한의과대학 신경정신과학교실) ;
  • 구병수 (동국대학교 한의과대학 신경정신과학교실)
  • Published : 2003.06.30
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Abstract

Object : The present experiments were designed to study on the memory enhancement of the extract of Gongjadaesungjichimjung-bang(GDJB). Methods : The water extract of GCJB has been tested for its activities on memory enhancement by passive avoidance task in vivo and for its inhibitory effect on the acetylcholine esterase activity. Results : GDJB water extract significantly enhanced the memory at a concentration of 50mg/kg, but this effect did not proportionally increased at a dose of l00mg/kg and significantly inhibited the acetylcholine esterase activity in a dose-dependent manner in in vitro assay with IC50 value of 1.57mg/ml and also in in vivo assay. Conclusion : The extract of GDJB showed a memory enhancement as well as the inhibitory effect on acetylcholine esterase activity, which suggest that this prescription may be applied for the treatment of memory impairment.

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