Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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A Facile One-pot Synthesis of Fused 2-Thiouracils: Dipyrimidinopyridine, Pyrazolopyrimidine and Pyridazinopyrimidines

  • Youssif, Shaker (Department of Chemistry, Faculty of Science, University of Zagazig) ;
  • EI-Bahaie, Said (Department of Chemistry, Faculty of Science, University of Zagazig) ;
  • Nabih, Esam (Department of Chemistry, Faculty of Science, University of Zagazig)
  • Published : 2003.10.20
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Abstract

A novel fused thiouracil containing a heterocyclic ring system, dipyrimidinopyridine (3), has been prepared through the cyclization of compound 2. Compound 2 was formed by the formylation of 6-amino-2-thiouracil 1, pyrazolopyrimidines 8-10 via the heating of 6-arylhydrazono-2-thiouracils 5-7, compound 11, using Vilsmeier reagent with compound 4, pyrazolylpyrimidine 12, indolodiazinopyrimidine 14 and pyridazinopyrimidine 15. Pyridazino-pyrimidine 15 was formed by the condensation of compound 4 with acetylacetone, isatin and benzyl, respectively.

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References

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