Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
권호 표지
DOI QR코드

DOI QR Code

Analysis of Folate by Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry

  • Cha, Sang-Won (School of Chemistry & Molecular Engineering, Seoul National University) ;
  • Kim, Hie-Joon (School of Chemistry & Molecular Engineering, Seoul National University)
  • Published : 2003.09.20
Download PDF
⟨ Previous Next ⟩

Abstract

Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) was used to observe folic acid and its derivatives such as tetrahydrofolate and 5-methyltetrahydrofolate in a vitamin tablet and in foods. Folic acid in a vitamin tablet was determined using angiotensin I as an internal reference. Tetrahydrofolic acid, 5-methyltetrahydrofolic acid, and an oxygenated folate were observed from a human blood sample using graphite plate. The results show that these mass spectrometric methods are useful for quickly obtaining a profile of folates.

Keywords

References

  1. Blakley, R. L.; Benkovic, S. J. Folates and Pterines; John Wiley &Sons: New York, 1984; Vol. 1.
  2. Ottaway, P. B. The Technology of Vitamins in Food; Chapman &Hall: London, 1993; pp 1-41.
  3. Stokes, P.; Webb, K. J. Chromatogr. A 1999, 864, 59. https://doi.org/10.1016/S0021-9673(99)00992-9
  4. Stryer, L. Biochemistry; W. H. Freeman and Company: NewYork,1995.
  5. Shane, B.; Stockstad, E. L. R. J. Biol. Chem. 1975, 250, 2243.
  6. Babu, S.; Srikantia, S. G. Am. J. Clin. Nutr. 1976, 29, 376.
  7. Finglas, P. M.; Faure, U. Food Chem. 1993, 46, 199. https://doi.org/10.1016/0308-8146(93)90037-G
  8. Reingold, R. N.; Picciano, M. F. J. Chromatogr. 1982, 234, 171. https://doi.org/10.1016/S0021-9673(00)81790-2
  9. Wilson, S. D.; Horne, D. W. Anal. Biochem. 1984, 142, 529. https://doi.org/10.1016/0003-2697(84)90502-5
  10. Konings, E. J. M. J. AOAC. Int. 1999, 82, 119.
  11. Pfeiffer, C. M.; Rogers, L. M.; Gregory, J. F., Jr. J. Agric. Food.Chem. 1997, 45, 407. https://doi.org/10.1021/jf960633q
  12. Vahteristo, L. T.; Lehikoinen, K.; Ollilainen, V.; Varo, P. FoodChem. 1997, 59, 589. https://doi.org/10.1016/S0308-8146(96)00318-4
  13. Vahteristo, L. T.; Ollilainen, V.; Varo, P. J. Food Sci. 1996, 61, 524. https://doi.org/10.1111/j.1365-2621.1996.tb13148.x
  14. Vahteristo, L. T.; Ollilainen, V.; Koivistoinen, P. E.; Varo, P. J.Agric. Food. Chem. 1996, 44, 477. https://doi.org/10.1021/jf9503467
  15. Arnold, R. J.; Reilly, J. P. Anal. Biochem. 2000, 281, 45. https://doi.org/10.1006/abio.2000.4527
  16. Kim, H.-J.; Lee, J. K.; Park, S. J.; Ro, H. W.; Yoo, D. Y.; Yoon, D.Y. Anal. Chem. 2000, 72, 5673. https://doi.org/10.1021/ac0003899
  17. Abell, D. C.; Sporns, P. J. Agric. Food. Chem. 1996, 44, 2292. https://doi.org/10.1021/jf9507102
  18. Sugiyama, E.; Hara, A.; Uemura, K. Anal. Biochem. 1999, 274, 90. https://doi.org/10.1006/abio.1999.4245
  19. Bruenner, B. A.; Yip, T. T.; Hutchens, T. W. Rapid Commun. MassSpectrom. 1996, 10, 41.
  20. Jee, J.-G.; Park, S. J.; Kim, H.-J. Rapid Commun. Mass Spectrom.2000, 14, 1563. https://doi.org/10.1002/1097-0231(20000830)14:16<1563::AID-RCM45>3.0.CO;2-4
  21. Gapski, G. R.; Whiteley, J. M.; Huennekens, F. M. Biochemistry1971, 10, 2930. https://doi.org/10.1021/bi00791a021
  22. Sunner, J.; Dratz, E.; Chen, Y. C. Anal. Chem. 1995, 67, 4335. https://doi.org/10.1021/ac00119a021
  23. Dale, M. J.; Knochenmuss, R.; Zenobi, R. Anal. Chem. 1996, 68,3321. https://doi.org/10.1021/ac960558i
  24. Tanaka, K.; Ido, Y.; Akita, S.; Yoshida, Y.; Yoshida, T. Proc. 2ndJapan-China Joint Sympos. on Mass Spectrom. 1987, 185.
  25. Zumbuhl, S.; Knochenmuss, R.; Wulfert, S.; Dubois, F.; Dale, M.J.; Zenobi, R. Anal. Chem. 1998, 70, 707. https://doi.org/10.1021/ac970574v
  26. Kim, J.; Kang, W. Bull. Korean Chem. Soc. 2000, 21, 401.

Cited by

  1. Graphite Supported Preparation (GSP) of α-Cyano-4-Hydroxycinnamic Acid (CHCA) for Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry (MALDI-MS) for Peptides and Proteins vol.23, pp.11, 2012, https://doi.org/10.1007/s13361-012-0478-8
  2. Combination of graphite-assisted laser desorption/ionization (GALDI) mass spectrometry with thin layer chromatography vol.69, pp.14, 2014, https://doi.org/10.1134/S1061934814140032
  3. Characterization of Ionized Maltooligosaccharides by Sodium Cation in MALDI-TOFMS Depending on the Molecular Size vol.27, pp.8, 2003, https://doi.org/10.5012/bkcs.2006.27.8.1243
  4. The use of pencil lead as a matrix and calibrant for matrix-assisted laser desorption/ionisation vol.20, pp.7, 2006, https://doi.org/10.1002/rcm.2408
  5. Direct Formation of Silver Cluster Ions from Silver Salts by Laser Desorption/Ionization vol.28, pp.8, 2003, https://doi.org/10.5012/bkcs.2007.28.8.1437
  6. Laser desorption/ionization mass spectrometric analysis of folic acid, vancomycin and Triton® X‐100 on variously functionalized carbon nanotubes vol.27, pp.23, 2013, https://doi.org/10.1002/rcm.6728