Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Synthesis and Antiviral Evaluation of Novel Acyclic Nucleosides

  • Published : 2003.09.20
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Abstract

A very short and concise synthetic route for a novel acyclic version of d4T is described. The required quaternary carbon was successfully installed using a [3,3]-sigmatropic rearrangement. The condensation of the mesylates 16-18 with an adenine base under standard nucleophilic substitution conditions ($K_2CO_3$, 18-Crown- 6, DMF) in addition to deblocking afforded the target acyclic nucleosides 22-24. In addition, the antiviral evaluations against various viruses were performed.

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