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Heterocyclization Reaction of 4-(2-Methylaziridin-1-yl)-3-ureidobenzotrifluorides under Appel's Conditions

  • Cho, Hyun-In (Department of Chemical Engineering, Hanyang University) ;
  • Lee, Kee-Jung (Department of Chemical Engineering, Hanyang University)
  • Published : 2003.02.20
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Abstract

The reaction of 4-(2-methylaziridin-1-yl)-3-ureidobenzotrifluorides 4 with triphenylphosphine, carbon tetrachloride, and triethylamine (Appel's condition) led to the corresponding carbodiimides 5, which underwent intramolecular cycloaddition reaction with aziridine under the reaction condition to give the benzimidazolefused heterocycles, 2,3-dihydro-1H-imidazo[1,2-a]benzimidazoles 8 and 12,13-dihydro-5H-benzimidazo[2,3-b] [1,3]benzodiazepines 9.

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References

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Cited by

  1. ]-[1,3]benzodiazocines vol.41, pp.5, 2004, https://doi.org/10.1002/jhet.5570410525
  2. Heterocyclization Reaction of 4-(2-Methylaziridin-1-yl)-3-ureidobenzotrifluorides under Appel′s Conditions. vol.34, pp.26, 2003, https://doi.org/10.1002/chin.200326139