Journal of the Korean Chemical Society (대한화학회지)

Korean Chemical Society (대한화학회)
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Partial Synthesis of Fibrostatins

Fibrostatins의 부분 합성

  • Kwan Hee Lee (School of Life and Food Science, Handong University) ;
  • Harold w. Moore (Department of Chemistry, Uniersity of California at Irvine)
  • 이관희 (한동대학교 생명식품과학부) ;
  • Published : 2003.02.20
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Abstract

Fibrosstatins, which were isolated from the culture broth of Streptomyces catanulae subsp. griseospora, are naphthoquinones which can work as alkylating agents. It is important to synthesize these quinone compounds for the study of their biological activities. In this paper, an efficient method, Hooker oxidation, to control the regiochemistry in the synthesis of fibrostatin B is reported.

알킬화제로 작용할 수 있는 naphthoquinones인 fibrostatin이 Streptomyces catanulae subsp. griseospora 배양액으로부터 추출되었다. 이들 quinone 화합물의 합성은 이 화합물들의 생물학적 반응성 연구에 매우 중요하다. 본 논문에서는 효과적으로 치환체들의 위치를 조절할 수 있는 방법인 Hooker oxidation을 이용하여 fibrostatin B를 합성하였다.

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References

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