Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Convenient Synthesis of Optically Pure α-Mono and α,α-Disubstituted β-Amino Acids

  • Lee, Hyun-Soo (Center for Integrated Molecular Systems, Division of Molecular and Life Sciences,Pohang University of Science and Technology) ;
  • Park, Jung-Dae (Center for Integrated Molecular Systems, Division of Molecular and Life Sciences,Pohang University of Science and Technology) ;
  • Kim, Dong-H. (Center for Integrated Molecular Systems, Division of Molecular and Life Sciences,Pohang University of Science and Technology)
  • Published : 2003.04.20
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Abstract

Optically pure α-mono- and α, α-disubstituted β-amino acids were conveniently prepared in four steps and in 27-40% overall yields from the correspondingly substituted racemic β-hydroxy acids that can be readily obtained from diethyl malonate. In the synthesis, (S)-phenylethylamine has been used as a resolving agent and as a source of the amino group in the β-amino acids.

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References

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