Journal of the Korean Chemical Society (대한화학회지)

Korean Chemical Society (대한화학회)
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Synthesis and Anti-inflammatory Activity of [2-(Benzothiazol-2-ylimino)-4-oxo-3-phenylthiazolidin-5-yl]-acetic Acid Derivatives

  • Sushilkumar S. Bahekar (Department of Chemical Technology, Dr. Babasaheb Ambedkar Marathwada University) ;
  • Devanand B. Shinde (Department of Chemical Technology, Dr. Babasaheb Ambedkar Marathwada University)
  • Published : 2003.06.20
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Abstract

A synthetic method for the title compounds (2a-o) was carried out. The title compounds (2a-o)were prepared by the condensation of various thioureas and maleic anhydride. Anti-inflammatory activities in vivo were evaluated and compared with standard drug diclofenac sodium. Some compounds showed moderate activity. The structures of all the new compounds were established on the basis of $^1H$ NMR and IR spectral data.

소염작용을 가진 일련의 싸이아졸리딘아세트산 유도체들을 싸이오유레아와 말레산무수물로부터 합성하고 분광학적인 방법으로 구조를 확립하였다. 또한 이 화합물들의 소염작용을 표준시약인 디클로펜악 소듐과 비교한 결과 어느정도의 효과를 가지고 있음을 검정하였다.

Keywords

References

  1. Jury, P. F. In Chemistry and Pharmacology; Edited byR.A. Scherrer and M.W. Whitehouse Academic pressNew York, U. S. A., 1974; Vol. 1, p 92.
  2. Daniel, Lednicer; Lester A. Mitscher, In Organic Chemistry of Drug Synthesis, John Wiley and Sons,New York, U. S. A., 1980; Vol. 2, p 222.
  3. Andrisano M. G; Di Bella M; Ferrari P; Raffa L; BaggioG. G. Farmaco [Sci] 1981, 36(11), 905.
  4. Kentoro, H.; Hirohiko S. Chem. Pharm. Bull. 1977, 25,2292. https://doi.org/10.1248/cpb.25.2292
  5. Sawhney, S. N.; Dhindsa, G. S.; Singh S. P. Indian J.Chemistry 1983, 22B, 1044.
  6. Om Parkash; Shobhna Saini; Neena Saini; Indra Prakash.;Shiv P. Singh; Indian J. Chemistry, 1975, 34(B), 660.
  7. Kocabalkanli A.; Ates O.; Otuk G. Arch Pharm (Weinheim)2001, 334(2), 35. https://doi.org/10.1002/1521-4184(200102)334:2<35::AID-ARDP35>3.0.CO;2-4
  8. Capan G.; Ulusoy N.; Ergenc N.; Cevdet Ekinci A.;Vidin A. Farmaco. 1996, 51(11), 729.
  9. Ates O.; Kocabalkanli A.; Sanis G. O.; Ekinci A. C.; Vidin A. Arzneimittelforschung 1997, 47(10),1134.
  10. Abdel-Rahman R.M. Boll Chim Farm 2001, 140(6),401.
  11. Tripathi M.; Verma M.; Gujrati V. R.; Palit G.; ShankerK. Arzneimittelforschung 1993, 43(6), 632.
  12. Trivedi J. P.; Contractor S. J.; Shah I. D.; Jour. IndianChem. Soc. 1966, I, 265
  13. Winter, C. A.; Fisley, E. A.; Nuss, G. W. Proc. Soc.Exp. Biol. Med. 1962, 111, 544. https://doi.org/10.3181/00379727-111-27849

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