Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
권호 표지
DOI QR코드

DOI QR Code

Synthesis of Bis-pyridinium Oxime Antidotes Using Bis(methylsulfonoxymethyl) Ether for Organophosphate Nerve Agents

  • Yang, Garp-Yeol (Medicinal Science Division, Korea Research Institute of Chemical Technology) ;
  • Yoon, Joong-Ho (Medicinal Science Division, Korea Research Institute of Chemical Technology) ;
  • Seong, Churl-Min (Medicinal Science Division, Korea Research Institute of Chemical Technology) ;
  • Park, No-Sang (Medicinal Science Division, Korea Research Institute of Chemical Technology) ;
  • Jung, Young-Sik (Medicinal Science Division, Korea Research Institute of Chemical Technology)
  • Published : 2003.09.20
Download PDF
⟨ Previous Next ⟩

Abstract

Keywords

References

  1. Marrs, T. C. Pharmacol. Ther. 1993, 58, 51-66. https://doi.org/10.1016/0163-7258(93)90066-M
  2. Dawson, R.M. J. Appl. Toxicol. 1994, 14, 317-331. https://doi.org/10.1002/jat.2550140502
  3. Bajgar, J. Acta Med. 1996, 39, 101-105.
  4. Leadbeater, L.; Inns, R. H.; Rylands, J. M. Fundam. Appl.Toxicol. 1985, 5, S225-231. https://doi.org/10.1016/0272-0590(85)90132-0
  5. Thiermann, H.; Seidl, S.; Eyer, P. Int. J. Pharm. 1996, 137,167-176. https://doi.org/10.1016/0378-5173(96)04511-5
  6. Aas, P. Eur. J. Pharmcol. 1996, 301, 59-66. https://doi.org/10.1016/0014-2999(96)00027-1
  7. Lallement, G.; Clarencon, D.; Brochier, G.; Baubichon, D.;Galonnier, M.; Blanchet, G.; Mestries, J. Pharmacol. Biochem.Behav. 1997, 56, 325-332. https://doi.org/10.1016/S0091-3057(96)00292-4
  8. Hagedorn, I. USP 3,852,294, 1974.
  9. Burness, D. M.; Wright, C. J.; Perkins, W. C. J. Org. Chem.1977, 42, 2910-2913. https://doi.org/10.1021/jo00437a028
  10. Wadsworth, D. H.; Vinal, R. S. J. Org. Chem. 1982, 47, 1623-1626. https://doi.org/10.1021/jo00348a003

Cited by

  1. Evaluation of Newly Synthesized Reactivators of the Brain Cholinesterase Inhibited by Sarin Nerve Agent vol.15, pp.4, 2005, https://doi.org/10.1080/15376520590968770
  2. Synthesis of a novel series of bispyridinium compounds bearing a xylene linker and evaluation of their reactivation activity against chlorpyrifos-inhibited acetylcholinesterase vol.20, pp.5, 2005, https://doi.org/10.1080/14756360500179762
  3. New group of xylene linker-containing acetylcholinesterase reactivators as antidotes against the nerve agent cyclosarin vol.21, pp.5, 2006, https://doi.org/10.1080/14756360600741420
  4. In Vitro Potency of H Oximes (HI-6, HLö-7), the Oxime BI-6, and Currently Used Oximes (Pralidoxime, Obidoxime, Trimedoxime) to Reactivate Nerve Agent-Inhibited Rat Brain Acetylcholinesterase vol.69, pp.15, 2006, https://doi.org/10.1080/15287390500364283
  5. Targeted Synthesis of 1-(4-Hydroxyiminomethylpyridinium)-3-pyridiniumpropane Dibromide – A New Nerve Agent Reactivator vol.12, pp.8, 2007, https://doi.org/10.3390/12081964
  6. Purity of antidotal oxime HI-6 DMS as an active pharmaceutical ingredient for auto-injectors and infusions vol.4, pp.3-4, 2012, https://doi.org/10.1002/dta.357
  7. Evaluation of the Influence of Three Newly Developed Bispyridinium Anti-nicotinic Compounds (MB408, MB442, MB444) on the Efficacy of Antidotal Treatment of Nerve Agent Poisoning in Mice pp.17427835, 2017, https://doi.org/10.1111/bcpt.12935
  8. TLC analysis of twelve different salts of oxime HI-6 — Reactivator of nerve agent inhibited AChE vol.24, pp.2, 2011, https://doi.org/10.1556/JPC.24.2011.2.3
  9. Reactivation of organophosphate-inhibited acetylcholinesterase by quaternary pyridinium aldoximes vol.6, pp.7-8, 2004, https://doi.org/10.1007/BF03033452
  10. Reactivation of sarin-inhibited pig brain acetylcholinesterase using oxime antidotes vol.2, pp.4, 2006, https://doi.org/10.1007/BF03161181
  11. Reactivation of Human Brain Homogenate Cholinesterases Inhibited by Tabun using Newly Developed Oximes K117 and K127 vol.105, pp.3, 2009, https://doi.org/10.1111/j.1742-7843.2009.00421.x
  12. Synthesis of Bis-pyridinium Oxime Antidotes Using Bis(methylsulfonoxymethyl) Ether for Organophosphate Nerve Agents. vol.35, pp.8, 2004, https://doi.org/10.1002/chin.200408129
  13. In Vitro Evaluation of Acetylcholinesterase Reactivators as Potential Antidotes Against Tabun Nerve Agent Poisonings vol.29, pp.4, 2003, https://doi.org/10.1080/01480540600718565
  14. Reactivation Potency of New Group of Acetylcholinesterase Reactivators and Their Comparison with Currently Available Oximes vol.49, pp.4, 2006, https://doi.org/10.14712/18059694.2017.138
  15. In vitro Evaluation of New Acetylcholinesterase Reactivators as Casual Antidotes against Tabun and Cyclosarin vol.27, pp.3, 2003, https://doi.org/10.5012/bkcs.2006.27.3.395
  16. Potency of Several Structurally Different Acetylcholinesterase Reactivators to Reactivate House Fly and Bovine Acetylcholinesterases Inhibited by Paraoxon and DFP vol.27, pp.9, 2003, https://doi.org/10.5012/bkcs.2006.27.9.1401
  17. Potency of Novel Oximes to Reactivate Sarin Inhibited Human Cholinesterases vol.31, pp.1, 2003, https://doi.org/10.1080/01480540701688238
  18. Molecular dynamics of 6‐methyl‐2‐phenyl‐2,3‐dihydro‐4H‐chromen‐4‐one and 6‐methyl‐2‐(4‐nitrophenyl)‐2,3‐dihydr vol.51, pp.4, 2003, https://doi.org/10.1002/mrc.3933
  19. Microwave-Assisted Synthesis of Chiral Oxime Ethers vol.16, pp.6, 2003, https://doi.org/10.2174/1570178615666181106125853