Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Isolation and Synthesis of Tryptamine Derivatives from a Symbiotic Bacterium Xenorhabdus nematophilus PC

  • Paik, Seung-Uk (Faculty of Chemical & Materials Engineering, Keimyung University) ;
  • Park, Myung-Kwang (Faculty of Chemical & Materials Engineering, Keimyung University) ;
  • Jhun, Seong-Hoon (Faculty of Chemical & Materials Engineering, Keimyung University) ;
  • Park, Heai-Ku (Faculty of Chemical & Materials Engineering, Keimyung University) ;
  • Lee, Chun-Soo (Faculty of Chemical & Materials Engineering, Keimyung University) ;
  • Cho, Bum-Rae (Faculty of Chemical & Materials Engineering, Keimyung University) ;
  • Byun, Hong-Sik (Faculty of Chemical & Materials Engineering, Keimyung University) ;
  • Choe, Seok-Burm (Faculty of Chemical & Materials Engineering, Keimyung University) ;
  • Suh, Seong-Il (Department of Microbiology, School of Medicine, Keimyung University)
  • Published : 2003.05.20
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Abstract

Nematophin and its analog incorporating tryptamine unit have been isolated and characterized from strain XRPC of a symbiotic bacterium Xenorhabdus nematophilus, which was newly isolated from Korean entomopathogenic nematodes. The stereoselective synthesis of these compounds was accomplished, and the relative configurations were determined. Nematophin exhibited potent antibacterial activities over several strains of methicillin-resistant S. aureus (MRSA) comparable to those of vancomycin.

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