The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
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Effect of Yanggyuksanhwa-tang on c-Fos and c-Jun Expression in Ischemic Damaged Hippocampus of Aged BCAO Rats

노령 흰쥐의 뇌허혈 손상시 양격산화탕(凉膈散火湯)이 뇌해마의 c-Fos 및 c-Jun 발현에 미치는 영향

  • Kim Seung-Jun (Department of Anatomy, College of Oriental Medicine, Kyung Hee University) ;
  • Shin Jung-Won (Department of Neuroscience, Graduate School of East-West Medical Science, Kyung Hee University) ;
  • Sohn Young-Joo (Department of Neuroscience, Graduate School of East-West Medical Science, Kyung Hee University) ;
  • Jung Hyuk-Sang (Department of Anatomy, Colege of Oriental Medicine, Kyung Hee University) ;
  • Won Ran (Department of Neuroscience, Graduate School of East-West Medical Science, Kyung Hee University) ;
  • Sohn Nak-Won (Department of Neuroscience, Graduate School of East-West Medical Science, Kyung Hee University)
  • 김성준 (경희대학교 한의과대학 해부학교실) ;
  • 신정원 (경희대학교 동서의학대학원 신경과학교실) ;
  • 손영주 (경희대학교 동서의학대학원 신경과학교실) ;
  • 정혁상 (경희대학교 한의과대학 해부학교실) ;
  • 원란 (경희대학교 동서의학대학원 신경과학교실) ;
  • 손낙원 (경희대학교 동서의학대학원 신경과학교실)
  • Published : 2003.06.01
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Abstract

This study investigated the effect of Yanggyuksanhwa-tang on cerebral ischemia of the rats. Considering age-related impact on cerebral ischemia, aged rats (18 months old) were used for this study. Ischemic damage was induced by the transient occlusion of bilateral common carotid arteries(BCAO) under the hypotension. Yanggyuksanhwa-tang was administered twice orally. Then changes of immunohistochemical expression of c-fos and c-jun in ischemic damaged hippocampus were observed. The BCAO in aged rats led significant increase of c-fos expression in CA1 and DG of hippocampus. While the treatment of Yanggyuksanhwa-tang significantly attenuated the increase of c-fos expression in CA1 hippocampus following BCAO ischemia. Depending on changes of the normalized optical density(NOD) of immunohistochemical c-fos expression, the treatment of Yanggyuksanhwa-tang significantly attenuated the increase of NOD in CA1 and DG of hippocampus. And there was not changes in CA2 and CA3 hippocampus with respect to the control BCAO group. The BCAO in aged rats led significant increase of c-jun expression in CA1 hippocampus. While the treatment of Yanggyuksanhwa-tang significantly attenuated the increase of c-jun expression in CA1 hippocampus following BCAO ischemia. Depending on changes of the NOD of immunohistochemical c-jun expression, the treatment of Yanggyuksanhwa-tang significantly attenuated the increase of NOD in CA1 hippocampus. And there was not changes in CA2, CA3 and DG of hippocampus with respect to the control BCAO group.

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