대한한방내과학회지 (The Journal of Internal Korean Medicine)

대한한방내과학회 (The Society of Internal Korean Medicine)
권호 표지

Mouse의 십이지장 점막 염증에 대한 사삼맥문동탕의 면역반응 연구

The Effects of Sasammaickmoondong-tang against Duodenal Mucosal Lesions

  • 임성우 (동국대학교 한의과대학 내과학교실) ;
  • 최준혁 (동국대학교 한의과대학 내과학교실)
  • Lim Seong-Woo (Department of Internal Medicine, College of Oriental Medicine, Dongguk University) ;
  • Choi Jun-Hyuk (Department of Internal Medicine, College of Oriental Medicine, Dongguk University)
  • 발행 : 2003.06.01
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초록

Objectives : This study was carried out to investigate the effects of Sasammaickmoondong-tang(SME) on duodenal mucosal lesions induced by indomethacin in mouse. Methods : The normal group is that no inflammation elicitated mouse. Control group is that gastro-inflammation elicitated mouse. Sample group is that SME administered mouseice after gastro-inflammation elicitation. Results : In the common morphology and histochemical change, control group was observed various injury-mucous surface cell, micro-villi, paneth cell, surface epithelial cell, goblet cell-by hemorrhagic erosion, while sample group was as same as normal group. In the immunohistochemical change, the distributions of COX-1, Bcl-2, and BrdU treated with SME noticeably increased than control group(p<0.05). The distributions of TUNEL, $NF-{\kappa}B$, COX-2, $IL-2R-{\alpha}$, NK-1.1, ICAM-1, and CD11b/18 treated with SME noticeably decreased than control group(p<0.05). And the distribution of SBA was as same as normal group. Conclusion : According to the above results, it is supposed that Sasammaickmoondong-tang is applicable to duodenal mucosal lesions.

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