The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
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The Inhibitory Effects of SoCheongRyongTang(SCRT) on Cytokine Production and Secretion of IgE in Highly Purified Mouse B cells

생쥐의 B 세포에서 IgE의 분비와 Cytokine 생산에 대한 소청룡탕(小靑龍湯)의 효과(效果)

  • Lee Joung-Eun (Department of Internal Medicine College of Oriental Medicine, Daejeon University) ;
  • Han Young-Ju (Department of Internal Medicine College of Oriental Medicine, Daejeon University) ;
  • Park Yang-Chun (Department of Internal Medicine College of Oriental Medicine, Daejeon University) ;
  • Bae Han-Ho (Department of Internal Medicine College of Oriental Medicine, Daejeon University)
  • 이정은 (대전대학교 부속 한방병원 호흡기내과) ;
  • 한영주 (대전대학교 부속 한방병원 호흡기내과) ;
  • 박양춘 (대전대학교 부속 한방병원 호흡기내과) ;
  • 배한호 (대전대학교 부속 한방병원 호흡기내과)
  • Published : 2003.06.01
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Abstract

Objective : We aimed to identify the inhibitory effects of SocheongRyoungTang on Cytokine Production and Secretion of IgE in Highly Purified Mouse B cells. This experiment was designed to investigate the effect of SoCheongRyongTang(SCRT) on Antiallergy. Materials and Methods : We measured the cytotoxic activity for cytokines transcript expression, production of $IL-1{\beta},\;IL-4,\;IL-6,\;IL-10,\;IFN-{\gamma},\;TNF-{\alpha},\;TGF-{\beta}$ proliferation of B cell in anti-CD40mAb plus rIL-4 plus HRF stimulated murine splenic B cells and histamine in anti-CD40mAb plus rIL-4 plus HRF stimulated mast cells. Results : 1. SCRT increased the gene synthesis of $IFN-{\gamma}(m-RNA)$, the appearance of IL-10, $IFN-{\gamma}$. 2. SCRT decreased the gene synthesis of $IL-l{\beta},\;IL-4,\;TGF-{\beta}(m-RNA)$ and the appearance of $IL-l{\beta},\;IL-4,\;TGF-{\beta},\;IgE$ significantly. Conclusion : SCRT decreased the proliferation of B cell significantly. According to the above results, it is suggested that SCRT extract might be usefully applied for prevention and treatment of Allergic disease.

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