The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
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Effect of Banhabakchulchunma-tang on the Hepatic, Splenic and Cardiac Toxicity induced by Doxorubicin

반하백출천마탕(半夏白朮天麻湯)이 Doxorubicin에 의해 유발(誘發)된 독성(毒性)에 미치는 영향(影響)

  • Kim Bong-Suk (Department of Internal Medicine, College of Oriental Medicine, Kyungsan University) ;
  • Oh Jung-Han (Department of Internal Medicine, College of Oriental Medicine, Kyungsan University) ;
  • Lim Hee-Yong (Department of Internal Medicine, College of Oriental Medicine, Kyungsan University) ;
  • Beak Jung-Han (Department of Pediatrics, College of Oriental Medicine, Kyungsan University) ;
  • Park Chi-Sang (Department of Internal Medicine, College of Oriental Medicine, Kyungsan University) ;
  • Kim Sang-Chan (Department of Formulae Pharmacology, College of Oriental Medicine, Kyungsan University) ;
  • Byun Joon-Seok (Department of Internal Medicine, College of Oriental Medicine, Kyungsan University) ;
  • Hwang Hui-Jeung (Department of Internal Medicine, College of Oriental Medicine, Kyungsan University)
  • 김봉석 (경산대학교 한의과대학 내과학교실) ;
  • 오중환 (경산대학교 한의과대학 내과학교실) ;
  • 임희용 (경산대학교 한의과대학 내과학교실) ;
  • 백정한 (경산대학교 한의과대학 소아과교실) ;
  • 박치상 (경산대학교 한의과대학 내과학교실) ;
  • 김상찬 (경산대학교 한의과대학 방제학교실) ;
  • 변준석 (경산대학교 한의과대학 내과학교실) ;
  • 황희정 (경산대학교 한의과대학 내과학교실)
  • Published : 2003.06.01
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Abstract

Object : The effect of Banhabakchulchunma-tang extracts on the hepatic, splenic and cardiac toxicity induced by Doxorubicin administration(Three injection protocol) were monitored using male ICR mice. Methods : The changes of body weight, clinical signs, necropsy findings and organ weights of liver, spleen and heart were observed with blood GOT and GPT levels. Results : 1. Decrease of body weight and The degrees of anorexia, ataxia and dehydration after Doxorubicin treatment were dose-dependently inhibited by Banhabakchulchunma-tang extracts. 2. Increase of absolute and relative liver and heart weight observed in Doxorubicin treatment group were dose-dependently inhibited by Banhabakchulchunma-tang extracts. In addition, the degrees of liver congestion necrotic spot and the degrees of heart congestion enlargement were dose-dependently decreased after Banhabakchulchunma-tang extracts dosing groups compared to that of doxorubicin treatment group. It is also demonstrated that elevated serum GOT and GPT levels in doxorubicin treatment group were significantly decreased in Banhabakchulchunma-tang extracts dosing groups. 3. Decrease of absolute and relative spleen weight observed in doxorubicin treatment group were dose-dependently inhibited by Banhabakchulchunma-tang extracts. In addition, the degrees of splenic atrophy were significantly and dose-dependently decreased after Banhabakchulchunma-tang extracts dosing groups compared to that of doxorubicin treatment group. Conclusion : the toxicity of doxorubicin treatment(decrease of body weights, clinical signs such as anorexia, ataxia and dehydration, changes of organ weights of liver, spleen and heart, elevation of serum GOT and GPT levels) was inhibited and/or prevented by Banhabakchulchunma-tang extracts. According to these results, it is considered that Banhabakchulchunma-tang has some preventive effect against to doxorubicin induced toxicity.

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