대한한방내과학회지 (The Journal of Internal Korean Medicine)
- 제24권1호
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- Pages.94-103
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- 2003
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- 1226-9174(pISSN)
계지복령환(桂枝茯笭丸), 소복축어탕(少腹逐瘀湯), 도홍사물탕(桃紅四物湯)이 메산지움세포 증식과 Fibronectin 합성에 미치는 영향(影響)
The Experimental Studies Of The Kaejibokryungwhan, Sobokchugeotang And Dohongsamultang On The Mesangial Cell Proliferation And Fibronectin Synthesis
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안영민
(경희대학교 한의과대학 신계내과학교실) ;
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안세영
(경희대학교 한의과대학 신계내과학교실) ;
- 두호경 (경희대학교 한의과대학 신계내과학교실) ;
- 권영구 (경희대학교 한의과대학 신계내과학교실)
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Ahn Young-Min
(Department of 6th Internal Medicine, College of Oriental Medicine, Kyung Hee University) ;
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Ahn Se-Young
(Department of 6th Internal Medicine, College of Oriental Medicine, Kyung Hee University) ;
- Doo Ho-Kyung (Department of 6th Internal Medicine, College of Oriental Medicine, Kyung Hee University) ;
- Kwon Young-Ku (Department of 6th Internal Medicine, College of Oriental Medicine, Kyung Hee University)
- 발행 : 2003.03.01
초록
In order to investigate the effects of Kaejibokryungwhan, Sobokchugeotang and Dohongsamultang on mesangial cell proliferation and fibronectin synthesis, laboratory study was performed. The results are summarized as follows; 1. Mesangial cell proliferation was significantly decreased in the Kaejibokryungwhan group and the Dohongsamultang group compared with the Control group. In the Sobokchugeotang group, the mesangia1 cell proliferation activity was lesser than Control group, but it was statistically non-significant. In Kaejibokryungwhan group, the Sobokchugeotang group and Dohongsamultang group, mesangial cell proliferation was significantly decreased compared with the Hydrocortisone group 2. In the group, which contained fetal bovine serum, fibronectin synthesis was decreased in the Kaejibokryungwhan group, the Sobokchugeotang group and Dohongsamultang group compared with Control group, but the difference was statistically non-significant. In Kaejibokryungwhan group, Sobokchugeotang group and Dohongsamultang group, fibronectin was less decreased compared with that of Hydrocortisone group. 3. In the group, which contained fetal bovine serum, fibronectin synthesis was significantly decreased in Kaejibokryungwhan group and Sobokchugeotang group than those of Control group. In Dohongsamultang group, the fibronectin synthesis was decreased than Control group, but the difference was statistically non-significant. In Sobokchugeotang group, the fibronectin synthesis was decreased than Hydrocortisone group, but it was statistically non-significant. According to the above results, the mesangial cell proliferation and fibronectin systhesis could be reduced by Kaejibokryungwhan group significantly.
키워드