The Journal of Internal Korean Medicine (대한한방내과학회지)
- Volume 24 Issue 1
- /
- Pages.33-43
- /
- 2003
- /
- 1226-9174(pISSN)
The effects of the abstracts from Moutan Cortex on an anti-allergic action on B cells and mast cells of the BALB/C mouse
B 임파구(淋巴球)와 비만세포(肥滿細胞)에서 모단피(牡丹皮) 추출물(抽出物)의 항(抗)알러지 작용(作用)에 관(關)한 연구(硏究)
- Jeen Sok-Chang (Dong Seo Hosptial of Oriental Medicine) ;
- Kim Sung-Kyun (College of Oriental Medicine, Taejon University) ;
- Lee Han-Bae (College of Oriental Medicine, Taejon University) ;
- Lee Seung-Hee (College of Oriental Medicine, Taejon University) ;
- Seo Young-Bae (College of Oriental Medicine, Taejon University) ;
- Lee Yong-Gu (College of Oriental Medicine, Taejon University) ;
- Lee Young-Chul (College of Oriental Medicine, Taejon University) ;
- Jang Sung-Ik (Hae Dang Hosptial of Oriental Medicine)
- 진속창 (동서한방병원) ;
- 이한배 (대전대학교) ;
- 김성균 (대전대학교) ;
- 이승희 (대전대학교) ;
- 서영배 (대전대학교) ;
- 이용구 (대전대학교) ;
- 이영철 (대전대학교) ;
- 장성익 (혜당한방병원)
- Published : 2003.03.01
Abstract
Objective : This study was carried out for the purpose of proving the effect of anti-allergic efficacy on B cells and the mast cells of the BALB/C mouse by the abstraction from a Moutan cortex. Methods & Results : In order to know what the effect of an abstraction from Moutan cortex and about the expression of CD23 and IgE, IC-2 cell (mouse mast precursor cells that was dependent on IL-3), it was necessary to be activated. We then analyzed it from the flow of cytometry on the increase and the divorce of the B cells activated by anti-CD40. In order to know what the effect of it was on the organization of cytokine gene expression from the increase and divorce of the B cells and allergic acting by Moutan cortex, we found it necessary to examine the IC-2 cells and B cells. At the same time, as we examined the histamine release of IC-2 cells by ELISA method, we also examined the effect of Moutan cortex on the increase and divorce of the B cells by 3H-thymidine uptake method. We then analyzed the release of IL-4, IgE and histamine. Conclusions : As a results, Moutan Cortex promoted blood supply by extending the blood vessel of nasal mucous, which was contracted by the hypertrophied nasal mucous.