Tuberculosis and Respiratory Diseases
- Volume 52 Issue 3
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- Pages.241-250
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- 2002
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- 1738-3536(pISSN)
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- 2005-6184(eISSN)
The Role of Lymphocyte Compartment and Cytokine in Coal Workers Pneumoconiosis
진폐증환자에서의 임파구 분획 및 싸이토카인의 역할
- Lee, Jung-Yeon (Department of Internal Medicine, College of Medicine, Konkuk University) ;
- Yoo, Kwang-Ha (Department of Internal Medicine, College of Medicine, Konkuk University) ;
- Ahn, Hae-Ryon (Department of Internal Medicine, College of Medicine, Konkuk University) ;
- Kim, Sung-Ryul (Department of Internal Medicine, College of Medicine, Konkuk University) ;
- Lee, Hae-Woon (Department of Internal Medicine, College of Medicine, Konkuk University) ;
- Ahn, Cheol-Min (Department of Internal Medicine, College of Medicine, Yonsei University) ;
- Kim, Hyung-Joong (Department of Internal Medicine, College of Medicine, Yonsei University)
- 이정연 (건국대학교 의과대학 내과학교실) ;
- 유광하 (건국대학교 의과대학 내과학교실) ;
- 안해련 (건국대학교 의과대학 내과학교실) ;
- 김성렬 (건국대학교 의과대학 내과학교실) ;
- 이해운 (건국대학교 의과대학 내과학교실) ;
- 안철민 (연세대학교 의과대학 내과학교실) ;
- 김형중 (연세대학교 의과대학 내과학교실)
- Published : 2002.03.30
Abstract
Background : Coal-worker's pneumoconiosis(CWP) is characterized by a chronic inflammatory lung reaction associated with macrophage accumulation in the alveolar spaces. CWP is usually divided into two stage : simple pneumoconiosis(SP) where there are a limited number of fibrotic lesions remain limited, with radiological opacities smaller than 1cm and progressive massive fibrosis(PMF), which is characterized by the development of a perifocal extensive fibrotic response of the lung and severe alterations in pulmonary function. In this study, the lymphocyte compartment and cytokine were evaluated by measuring the serum levels in the control, SP and PMF groups. Materials and Methods : The coal workers selected for this study were employees(patients?) of the Tae-Baek and Dong-Hae hospital. All were men, 45-76 years old and the mean duration of their exposure to coal dust was 23.2 years in the lymphocyte compartment and 24.3 years in the cytokine checked group. According to X-ray examination results, the patients were classified into either one of the SP, PMF categories. The normal controls examined were 26-70 years old men. The serum cytokine levels were estimated by using an end point enzyme immunoassay technique. Results : T lymphocyte, helper and suppressor T cells were highly related to pneumoconiosis in this study. A statistically significant decrease in the number of suppressor T lymphocytes was observed in the simple pneumoconiosis patients and at the same time, there was an increase in the lymphocyte index. Howevere, there was no statistically difference in the serum cytokines levels among the SP, PMF and control groups. Conclusion : T lymphocyte, helper T, and suppressor T cells may be highly related to the development of CWP compared to the control group particularly in the early stage of pneumoconiosis. The changes observed in the immunological system in patients with pneumoconiosis may lie at the bottom of the pathogenesis of fibrosis. Further study is needed to evaluate the lymphocyte compartment as a marker for pneumoconiosis development in the early stage.
연구배경 : 진폐증은 주로 분진흡입에 의해 폐실질에 섬유화를 일으키는 질환으로 만성염증에 의해 폐포내에 대식세포를 축적시키는 특정이 있으며, 크게 단순진폐증(SP)과 진행성 종괴성 폐섬유증(PMF)으로 구분된다. 본 연구의 목적은 진폐증 환자에서 질환의 심한 정도를 ILO 분류에 따라 SP, PMF로 구분한 후, 감염이나 기타 기저질환이 없는 상태에서 혈중 임파구 분획 및 싸이토카인의 농도를 비교한 것이다. 방 법 : 태백 중앙 병원과 영동 병원의 진폐증 환자 중 정밀 검사를 시행하기 위해 병원을 방문한 단순진폐증 환자와 입원 중이거나 정밀검사를 시행한 진행성 종괴성 폐섬유증 환자, 대조군을 대상으로 하였고, 대조군(C;10), 단순진폐증 (S;19), 진행성 종괴성 폐섬유증 (P;30명)에서 혈중 임파구 분획을, C(10), S(14), P(14명)에서 싸이토카인 (IFN-