Tuberculosis and Respiratory Diseases
- Volume 52 Issue 1
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- Pages.54-61
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- 2002
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- 1738-3536(pISSN)
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- 2005-6184(eISSN)
A Canine Model of Tracheal Stenosis Using Nd-YAG Laser
Nd-YAG laser를 이용한 기관협착 동물모델의 개발
- Kim, Jhin-Gook (Department of Thoracic Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
- Suh, Gee-Young (Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
- Chung, Man-Pyo (Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
- Kwon, O-Jung (Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
- Suh, Soo-Won (Department of Medical Engineering, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
- Kim, Ho-Joong (Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine)
- 김진국 (성균관대학교 의과대학, 삼성서울병원 흉부외과) ;
- 서지영 (성균관대학교 의과대학, 삼성서울병원 호흡기내과) ;
- 정만표 (성균관대학교 의과대학, 삼성서울병원 호흡기내과) ;
- 권오정 (성균관대학교 의과대학, 삼성서울병원 호흡기내과) ;
- 서수원 (성균관대학교 의과대학, 삼성서울병원 의공학과) ;
- 김호중 (성균관대학교 의과대학, 삼성서울병원 호흡기내과)
- Published : 2002.01.30
Abstract
Background: Tracheal stenosis is an urgent but uncommon disease. Therefore, primary care clinicians have limited clinical experience. Animal models of a tracheal stenosis can be used conveniently for the learning, teaching, and developing new diagnostic and therapeutic modalities for tracheal stenosis. Recently, a canine model of a tracheal stenosis was developed using a Nd-YAG laser. To describe the methods and results of developed animal model, we performed this study. Methods : Six Mongrel dogs were generally anesthetized and the anterior 180 degree of tracheal cartilage of the animal was photo-coagulated using a Nd-YAG laser. The animals were bronchoscopically evaluated every week for 4 weeks and a pathologic evaluation was also made. Results : Two weeks after the laser coagulation, the trachea began to stenose and the stenosis progressed through 4 weeks. All animals suffered from shortness of breath, wheezing, and weight loss in the 3 weeks after the laser treatment, and two died of respiratory failure just before the fourth week. The gross pathologic findings showed the loss of cartilage and a dense fibrosis, which resulted in a fibrous stricture of the trachea. Microscopy also showed that the fibrous granulation tissue replaced destroyed cartilage. Conclusion : The canine model can assist in the understanding and development of new diagnostic and therapeutic modalities for tracheal stenosis.
배 경 : 동물 모델을 이용하여 일정한 수준의 상기도 협착을 일으킬 수 있다면 이에 대한 임상교육에도 도움이 되며 새로운 진단법이나 치료법의 개발을 보다 쉽게 할 수 있을 것이다. 저자들은 한국산 잡견을 이용하여 Nd-YAG Laser 소작술로 기관 협착을 일정하게 유도하는데 성공하여, 이에 대해 기술하고자 본 연구를 시행하였다. 방 법 : 체중 22kg 정도의 한국산 잡견 6마리를 전신마취 시킨 후, Nd-YAG 레이저를 이용하여 4개의 기관 연골환의 전방부 180도를