IMMUNE NETWORK
- Volume 2 Issue 3
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- Pages.137-141
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- 2002
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- 1598-2629(pISSN)
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- 2092-6685(eISSN)
Identification of a Variant Form of Cellular Inhibitor of Apoptosis Protein (c-IAP2) That Contains a Disrupted Ring Domain
- Park, Sun-Mi (Department of Biology and Protein Network Research Center, Yonsei University) ;
- Kim, Ji-Su (Department of Biology and Protein Network Research Center, Yonsei University) ;
- Park, Ji-Hyun (Department of Biology and Protein Network Research Center, Yonsei University) ;
- Kang, Seung-Goo (Department of Biology and Protein Network Research Center, Yonsei University) ;
- Lee, Tae Ho (Department of Biology and Protein Network Research Center, Yonsei University)
- Published : 2002.09.30
Abstract
Among the members of the inhibitor of apoptosis (IAP) protein family, only Livin and survivin have been reported to have variant forms. We have found a variant form of c-IAP2 through the interaction with the X protein of HBV using the yeast two-hybrid system. In contrast to the wild-type c-IAP2, the variant form has two stretches of sequence in the RING domain that are repeated in the C-terminus that would disrupt the RING domain. We demonstrate that the variant form has an inhibitory effect on TNF-mediated