Involvement of Nitric Oxide and Prostanoid on Photorelaxation in Pig Renal Artery

UV-light 에 의한 혈관 이완작용에 있어서 nitric oxide와 prostanoid의 관련성

  • Kim, Joo-Heon (College of Veterinary Medicine, Gyeongsang National University and Institute of Animal Medicine) ;
  • Shim, Cheol-Soo (College of Veterinary Medicine, Gyeongsang National University and Institute of Animal Medicine) ;
  • Jeon, Seok-Cheol (Cardiac center, Mason Samsung General Hospital Masan)
  • 김주헌 (경상대학교 수의과대학, 동물의학연구소) ;
  • 심철수 (경상대학교 수의과대학, 동물의학연구소) ;
  • 전석철 (마산삼성병원 심장센터)
  • Accepted : 2002.08.29
  • Published : 2002.09.30

Abstract

The effect of nitric oxide synthase(NOS) inhibita, $N^G$-nitro-L-arginine-methyl ester(L-NAME) and prostanoid synthesis inhibiter, indomethacin on the photorelaxation, when was exposed to the long-wave length UV-light, was examined on the precontraction by the phenylephrine in the isolated pig renal artery. 1. UV-light relaxed both with-endothelium and without-endothelium in the pig renal arterial ring contracted by the phenylephrine. The magnitude of photorelaxation was dependent on the exposure time for UV-light. 2. UV-Iight induced relaxation was inhibited by L-NAME and indomethacin on the precontraction by the phenylephrine in the isolated pig renal artery. 3. UV-Iight induced relaxation was inhibited by methylene blue on the precontraction by the phenylephrine in the isolated pig renal artery. These results suggest that UV-light induced photorelaxation may be due to cGMP involved both nitric oxide and prostanoid on the precontraction by the phenylephrine in the isolated pig renal artery.

Keywords

References

  1. Furchgtt RF, Zawadzki JV. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature, 299 : 373-376, 1980
  2. Forstermann U, Neufang B. The endothelial mediated relaxation of rabbit aorta : Effects of antioxidants andrta. hydroxylated eicosatetranoic acids. Br J Pharmacol, 82: 765-767, 1984
  3. Griffith TM, Edward DH, Lewis MJ et al. The nature of endothelium derived vascular relaxant factor. Nature, 308 : 645-647, 1984
  4. Singer HA, Saye JA, Peach MJ. Effects of cytochrome P-450 Inhibitors on endothelium dependent relaxation in rabbit aorta. Blood vessel, 21 : 223-230, 1984
  5. Palmer RMJ Ferrige AG, Moncada S. Nitric oxide release accounts for the biologic activity of endothelium-derived relaxation factor. Nature, 327 : 524-527, 1987
  6. Ignarro LK. Endothelium-derived relaxing factcr produced and released from artery and vein is nitric oxide. Proc Natl Acad Sci USA, 84 : 9265-9269, 1987
  7. Mizumoto A, Mochiki E, Suzuki H et al. Neuronal control of motility changes in the canine lower esophageal sphincter and stomach in response to meal ingestion. J Smooth Muscle Res, 33 : 211-222, 1997
  8. Barbier AJ, Lefebvre RA. Influence of S-nitrosothiols and nitrate tolerancein the rat gastric fundus. Brit J Pharmacol, 111:1280-1286, 1994
  9. Li CG, Rand MJ. Nitric oxide and vasoactive intestinal peptide mediate non-adrenergic inhibitory transmission to smooth muscle of rat gastric fundus. Eur J Pharmacol, 191:303-309, 1990
  10. Mun KW, Kim JY, Kim TW et al. Nitric oxide mediating non-adrenergic noncholinergic relaxation in the boar retractor penis muscle. I Mediators of nonadrenergic, noncholinergic relaxation of porcine retractor penis muscle : nitric oxide and vasoactive intestinal polypeptide. Kor J Vet Res, 35:447-458, 1995
  11. Sheng H, Schmitt HHW, Nakane M et al. Characterization and isolation of nitric oxide synthase ib non-adrenergic noncholinergic nerves bovine retractorpeais muscles. Brit J Pharmacol, 106 : 768-773, 1992
  12. Chen X, Gillis CN. Methylene blue enhanced photore laxaticn in aorta, pulmonary artery and ccrpus cavernsum. Biochem Biophy Res Commun, 190 : 559-563, 1993
  13. Chang KC, Chong WS, Park BW et al. No- and $NO_2$-carrying molecule potentiate photorelaxation in rat trachea and aorta. Bioche Biophy Res Commun, 191: 509-514, 1993
  14. Stuehr DJ and Griffith OW. Mamamlian nitric oxide synthases. Adv Enzymol Rel Areas Mol Biol, 65 : 287-346, 1992
  15. Ehrreich SJ, Furchgott RF. Relaxation of mamalian smooth muscles by visible and ultraviolet radiation. Nature, 218:682-684, 1968
  16. Furchgott RF. Effects of various gents on photorelaxation of rabbit aortic strips. In Physiology and Pharmacology of Vascular Neureffector Systems, edited by Bevan JA, Furchgott RF, Maxwall RA, Sollyo AP. Basal:Karger, 247-262, 1971
  17. Burnstoch G. Purinergic receptors. J Theor Biol, 62 : 491-503, 1976
  18. Kim JH, Shim CS, Jeon SC. Involvement of nitric oxide and prostanoid on the endothelium-dependent vasodilatation by acetylcholine in the isolated rabbit renal artery. Kor J Vet Res, 42:299-304, 2001
  19. Kim TW, La JH, Yang IS, The inhibitory action of nitric oxide donor on the slow wave and spontaneous contraction in the guinea pig antral circular muscle. Kor J Vet Res, 40:691-699, 2000
  20. Zenge JP, Rairigh RL, Grover TR et al. NO and prostaglandin interactions during hemdynamic stress in the fetal ovine pulmonary circulaticai. Am J Physiol, 281 : L1157-1163, 2001
  21. Hurwitz A, Finci-Yeheskel Z, Milwidsky A et al. Regulation od cyclooxygenase activity and progesterone production in the rat corpus luteum by inducible nitric oxide synthase. Reproduction, 123:663-669, 2002
  22. Ahmad N, Chen LC, Gordon MA et al. Regulation of cyclooxygenase-2 by nitric oxide in activated hepatic macrophages during acute endotoxemia. J Leukoc Biol, 71:1005-1011, 2002
  23. Summy-Long JY, Bui V, Gestl S et al. Nitric oxide, interleukin and prostaglandin interactions affecting the magnocellular system. Brain Res, 940:10-20, 2002
  24. Furchgott RF, Jothianandan D. Endothelium-dependent and independent vasodilatation involving cGMP : Relaxation induced by nitric oxide, carbon monoxide and light. Blood vessels, 28:52-61, 1991
  25. Li HF, Zheng TZ, Li W et al. Effect of progesterone on the contractile response of isolated pulmonary artery in rabbits. Can J Physiol Pharmacol, 79:545-550, 2001