Journal of Haehwa Medicine (혜화의학회지)

Research Institute of Korean Medicine (대전대학교 한의학연구소)
권호 표지

Study on Antitumor Activity and Antimetastatic Effects of Bruceae Fructus(BF)

압단자(鴨蛋子)의 항암활성(抗癌活性) 및 항전이(抗轉移) 효과(效果)에 관(關)한 연구(硏究)

  • Lee, Dong-hoon (Dept. of Oriental Medicine Pathology, College of Oriental Medicine, Daejeon University) ;
  • Kim, Sung-hoon (Dept. of Oncology, Graduate School of East-West Medical Science, Kyunghee University) ;
  • Kim, Dong-hee (Dept. of Oriental Medicine Pathology, College of Oriental Medicine, Daejeon University)
  • 이동훈 (대전대학교 한의과대학 병리학교실) ;
  • 김성훈 (경희대학교 동서의학대학원) ;
  • 김동희 (대전대학교 한의과대학 병리학교실)
  • Published : 2002.02.08
Download PDF
⟨ Previous Next ⟩

Abstract

To evaluate the antitumor activity and antimetastatic effects of Bruceae FructusCBF), studies were done experimentally. The results were obtained as follows : 1. In cytotoxicity against A549, SK-MEL-2, MCF-7 and XF498 cell concentration inhibiting cell growth up to below 50% of control was recognized at $25{\mu}g/m{\ell}$ of BF. Also BF inhibited cell growth up to below 50% of control against HCT15 cell at $12.5{\mu}g/m{\ell}$, so it showed stronger cytotoxicity against HCT15 cell than another cancer cell. 2. In Inhibitory effect on activity of DNA topoisomerase- I, the $IC_{50}$ was shown $10-50{\mu}g/m{\ell}$ of BF. 3. The T/C% was 143.4 in BF treated group in S-180 bearing ICR mice. 4. The concentration inhibiting adhesion of A549 and SK-OV-3 to complex extracellular matrix up to below 30% of control was recognized at $1{\mu}g/m{\ell}$ of BF. 5. In pumonary colonization assay, a number of colonies in the lungs were decreased significantly in BF treated group as compared with control group. These results suggested that BF extracts might be usefully applied for prevention and treatment of cancer.

Keywords