Journal of dental hygiene science (치위생과학회지)
- Volume 2 Issue 1
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- Pages.15-19
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- 2002
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- 1598-4478(pISSN)
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- 2233-7679(eISSN)
Cytotoxicity on Cancer cells of the Extract of Sophora flavescens Ait.
고삼 추출물의 암세포에 대한 세포독성
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Lee, Hyun-Ok
(Department of Dental Hygiene, Wonkwang Health Science College) ;
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Chun, Ju-Yeon
(Department of Dental Hygiene, Wonkwang Health Science College) ;
- Lee, Ji-Youn (Department of Dental Hygiene, Wonkwang Health Science College) ;
- Kim, Chang-Hee (Department of Dental Hygiene, Shin-Sung College)
- Received : 2002.05.13
- Accepted : 2002.06.24
- Published : 2002.06.30
Abstract
In this study, we investigated the cytotoxicity of ethyl acetate subfraction of Sophora flavescens Ait.(EASS) on cancer cells using MTT quantitative analysis. The EASS was cytotoxicity from the concentration of 6.25 g/ml to KB, B16, HeLa, and MCF-7 cancer cells and the cytotoxicity was significant, (p < 005) increased as the concentrations of EASS were increased, (12.5, 25, 50, 100 g/ml). The IC for KB, B16, HeLa, and MCF-7 were 56.58, 65.43, 83.95, and 106.65 g/ml, respectively. Conclusively, the EASS inhabited the growth of cancer cells and the order of potency of cytotoxicity was KB > B16 > HeLa > MCF-7.
고삼 추출물의 암세포에 대한 세포독성을 파악하기 위하여 고삼의 에틸 아세테이트 소분획으로 MTT 정량분석을 실시하였다. 고삼의 에틸 아세테이트 소분획은 암세포인 KB 세포, B16 세포, HeLa 세포와 MCF-7 세포에 대하여