Korean Journal of Psychosomatic Medicine (정신신체의학)
- Volume 10 Issue 2
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- Pages.130-141
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- 2002
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- 1225-6471(pISSN)
Serum Levels of IL-$1\beta$ , IL-2 and IL-6 in Functional Gastrointestinal Disorders in Relation to Depression and Stressful Life Events
기능성 위장관 장애에서 혈청 IL-$1\beta$ , IL-2, IL-6의 변화 : 우울증 및 스트레스와의 상관성
- Park, Si-Sung (Department of Neuropsychiatry, Kosin University Medical College) ;
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Lee, Sang-Shin
(Department of Neuropsychiatry, Kosin University Medical College) ;
- Park, Moo-In (Department of Internal Medicine, Kosin University Medical College) ;
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Koo, Ja-Young
(Department of Internal Medicine, Kosin University Medical College) ;
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Park, Je-Min
(Department of Neuropsychiatry, School of Medicine, Pusan National University) ;
- Kim, Myung-Jung (Department of Neuropsychiatry, School of Medicine, Pusan National University)
- 박시성 (고신대학교 의과대학 신경정신과학교실) ;
-
이상신
(고신대학교 의과대학 신경정신과학교실) ;
- 박무인 (고신대학교 의과대학 내과학교실) ;
-
구자영
(고신대학교 의과대학 내과학교실) ;
-
박제민
(부산대학교 의과대학 신경정신과학교실) ;
- 김명정 (부산대학교 의과대학 신경정신과학교실)
- Published : 2002.12.15
Abstract
Objectives : Stress induces alteration of gastrointestinal function in which interleukin (IL) and hypothalamo-pituitary-axis are involved. Depression again is associated with functional gastrointestinal disorders (FGID) and interleukins. The author attempted to look into the role of interleukins in the FGID also the association of depression and stress in this context. Methods : Entered were 20 patients with FGID, diagnosed by Rome IT criteria and 20 healthy controls. Depression was measured by Hamilton Rating Scale for Depression (HAM-D), and stress of the last one year by Schedule of Recent Experience (SRE). Serum levels of IL-
스트레스가 위장관 기능을 변화시키며 이에는 interleukin과 시상하부-뇌하수체-부신피질 축이 관여한 다고 알려져 있다. 한편 우울증이 기능성 위장관 장애 및 interleukin과 연관성을 지닌다. 본 연구에서는 IL-