Journal of Periodontal and Implant Science

Korean Academy of Periodontology (대한치주과학회)
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An Assessment on effect of Bioabsorbable membrane, allogenic bone and Platelet Rich Plasma in Class II furcation involvement by digital subtraction radiography

2급 치근이개부 치료 시 흡수성 차폐막, 동종골 이식 및 혈소판 농축 혈장의 골 재생 효과에 대한 디지털 공제술의 정량적 분석

  • Kim, Sang-Hoon (Department of Periodontology, College of Dentistry, Dan-kook University) ;
  • Lim, Sung-Bin (Department of Periodontology, College of Dentistry, Dan-kook University) ;
  • Chung, Chin-Hyung (Department of Periodontology, College of Dentistry, Dan-kook University)
  • 김상훈 (단국대학교 치과대학 치주과학교실) ;
  • 임성빈 (단국대학교 치과대학 치주과학교실) ;
  • 정진형 (단국대학교 치과대학 치주과학교실)
  • Published : 2002.03.30
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Abstract

The purpose of this study was to evaluate effect of platelet rich plasma on the treatment of Grade II furcation involvement, with Demineralized Freeze-Dried Bone(Dembone(R)) and bioabsorable membrane(BioMesh(R)) in humans by digital subtraction radiography. 12 teeth(control group) were treated with Demineralized Freeze-Dried Bone(Dembone(R)) and bioabsorable membrane(BioMesh(R)), and 12 teeth(test group) were treated with Demineralized Freeze-Dried Bone(Dembone(R)), bioabsorable membrane(BioMesh(R)) and Platelet Rich Plasma. The change of bone density was assessed by digital subtraction radiography in this study. The change of mineral content by as much as 5%(vol) could be perceived in the subtracted images. The change of mineral content was assessed in the method that two radiographs are put into computer program to be overlapped and the previous image is subtracted by the later one. Both groups were statistically analyzed by Wilcoxon signed Ranks Test and Mann-whitney Test using SPSS program (5% significance level). The results were as follows: 1. In test group, the radiopacity in 3 months after surgery were significantly increased than 1 month after surgery(p<0.05). However. there were no significant difference between 1 month after surgery and 3 months after surgery in control group(p>0.05). 2. In test and control group, the radiopacity in 6 months after surgery were significantly increased than 1 month after surgery(p<0.05) 3. In test and control group, the radiopacity in 6 months after surgery were significantly increased than 3 months after surgery(p<0.05). 4. There were no significant difference between test group and control group at 1 month, 3 months after surgery, but radiopacity in test group were significantly increased than control group at 6 months after surgery(p<0.05). In conclusion, Platelet Rich Plasma can enhance bone density.

Keywords

References

  1. Edward S. Cohen : Atlas of Cosmetic and Reconstructive Periodontal Surgery, 2nd edition
  2. Glickman, I. : Clinical Periodontology,ed 7. Philadelphia, W. B. Sauders Co,1990
  3. Gottlow J, Nyman S : New attachment formation as the result of controlled tissue regeneration. J Clin Periodontol 1984; 11: 494-503 https://doi.org/10.1111/j.1600-051X.1984.tb00901.x
  4. Becker, W., Becker, B. E., Berg, L., Prichard, J., Caffesse, R. G. & Rosenberg, E. : New attachment after treatment with root isolation procedures in class III and class II furcations and vertical osseous defects. International Journal of Periodontology and Restorative Dentisty 1988;3:9-23
  5. Pontoriero, R., Nyman, S. : Guided tissue regeneration in degree Ⅱ furcation -involved mandibular molars. A clinical study. J Clin Periodontol 1988; 15: 247-254 https://doi.org/10.1111/j.1600-051X.1988.tb01578.x
  6. Machtei E, Dunford R. : Gingival recession and exposure of barrier membrane: effect on guided tissue regeneration of class II furcation defects. Int J Periodontics Restorative Dent 1995; 15: 590-599
  7. Lu H. : Topographical characteristes of root trunk length related to guided tissue regeneration. J Periodontol 1992; 63: 215-219 https://doi.org/10.1902/jop.1992.63.3.215
  8. Terranova VP, Hick S, Franzetti L, Lyall RM, Wikesso VME. : A biochemical approach to periodontaol regeneration, AFS CM, Assay for specific cell migration. J Periodontol 1987;58:247-259
  9. Terranova VP, Franzetti LC, Hick S, Wikesjo VME. : Biochemically mediated periodontal regeneration. J Periodont Res 1987;22:248-251 https://doi.org/10.1111/j.1600-0765.1987.tb01580.x
  10. Rutherford RB, Trilsmith MD, Ryan HE and Charette MF.: Synergistic effects of dexamethasone on platelet-derived growth factors mitogenesis in vitro. Arch Oral Biol 1992; 37: 139-145 https://doi.org/10.1016/0003-9969(92)90009-W
  11. Matsuda N, Lin WL, Kumar NM, Cho MI and Genco RJ.: Mitogenic chemotactic and synthetic responses of rat periodontal ligament fibroblastic cells to polypeptide growth factors in vitro. J Periodontol 1992; 63: 515-525 https://doi.org/10.1902/jop.1992.63.6.515
  12. Oates TW, Rouse CA and Cochra DI.: Mitogenic effects of growth factors on human periodontal ligament cells in vitro. J Periodontol 1993; 64: 142-148 https://doi.org/10.1902/jop.1993.64.2.142
  13. Giannobile WV, Finkelman RD and Lynch SE.: Comparison of canine and non-human primate animal models for periodontal regenerative therapy: Results following a single administration of PDGF/IGF-I. J Periodontol 1994; 65: 1158-1168 https://doi.org/10.1902/jop.1994.65.12.1158
  14. Sporn MB, Roberts AB, Wakefield LM and de Crombrugghe B.: Some recent advances in the chemistry and biology of TGF-$\beta$. J Cell Biol 1987; 105: 1039-1045 https://doi.org/10.1083/jcb.105.3.1039
  15. Keski-Oja J, Leof EB, Lyons RM, Coffey RJ and Jr. Moses HL.: Transforming growth factor and control of neoplastic cell growth. J Cell Biochem 1987; 33: 95-107 https://doi.org/10.1002/jcb.240330204
  16. Antosz ME, Bellows CG and Aubin JE.: Effects of TGF- $\beta$and epidermal growth factor on celll proliferation and the formation of bone nodules in isolated fetal rat calvaria cells. J Cell Physiol 1989; 140: 386-393 https://doi.org/10.1002/jcp.1041400225
  17. Centrella M, McCarthy TL and Canalis E. : TGF-$\beta$ is a bifunctional regulator of recplication and collagen synthesis in osteoblast-enriched cell cultures from fetal rat bone. J Bio Chem 1987; 262: 2874-2896
  18. Subburaman Mohan : Bone growth Factors. Clinical Orthopaedics and related research 1991; 263: 30-48
  19. Jeffcoat M. : Radiographic methods for dection of progressive alveolar bone loss. J Periodontol 1992; 63: 367-372 https://doi.org/10.1902/jop.1992.63.4s.367
  20. Stahl, S. Frou, S. : Histologic and clinical responses to porous hydroxylapatite implants in human periodontal defects. J Periodontol 1987; 58: 689-695 https://doi.org/10.1902/jop.1987.58.10.689
  21. Meffert, R. M., Thomas, J. R. : Hydroxylapatite as an alloplastic graft in the treatment of human periodontal osseous defects. J Periodontol 1985; 56: 63-73
  22. Isidor, F., Karring, T. : New attachment formation on citric acid treated roots. J Periodont. Res. 1985; 20: 421-430 https://doi.org/10.1111/j.1600-0765.1985.tb00454.x
  23. Nilveus, R. egelberg, J. : The effect of topical citrical acid application of the healing of experimental furcation defects in dogs. The relative importance of coagulum support, flap design and systemic antibiotics. J Periodont. Res. 1980; 15: 551-560 https://doi.org/10.1111/j.1600-0765.1980.tb00313.x
  24. Pontoriero, R., Nyman, S., Lindhe, J. : Guided tissue regeneration in surgically produced furcation defects. An experimental study in the beagle dogs. J Periodontol 1992; 19: 159-163 https://doi.org/10.1111/j.1600-051X.1992.tb00632.x
  25. Caffesse, R. G., Smith, B. A. : New attachment achieved by guided tissue regeneration in the beagle dogs. J Periodontol 1988; 59: 589-594 https://doi.org/10.1902/jop.1988.59.9.589
  26. Lynch SE. Williams RC, Polson AM, Howell TH, Reddy Ms, Zappa UE, Antoniades HN. : A combination of platelet-derived and insulin-like growth factors enhances periodontal regeneration. J Clin Periodontol 1989; 16: 545-548 https://doi.org/10.1111/j.1600-051X.1989.tb02334.x
  27. Lynch SE. : Platelet-derived growth factor and insulin-like growth factor. I. Mediators of healing in soft tissue and bone wounds. Periodont Case Rep 1991; 13: 13-20
  28. Rutherford, R. B., Hiekrash, C. E. : Plateletderived growth factor and insulin-like growth factors stimulate regeneration of periodontal attachment in monkeys. J Periodont. Res. 1992; 27: 285-290 https://doi.org/10.1111/j.1600-0765.1992.tb01679.x
  29. Wikesjo UME, Sigurdsson TJ: Guided Bone Regeneration: Is it a reproducible technique? J Parodontol Implantol Orale 1994; 13: 243-257
  30. Gottlow J, Nyman S, Lindhe J, Karring T: New Attachment Formation in the Human Periodontium by Guided Tissue Regeneration. J Clin Periodontol 1986; 13: 604-616 https://doi.org/10.1111/j.1600-051X.1986.tb00854.x
  31. Pontoriero, R., Lindhe, J., Nyman, S., Karring, T., Rosenberg, E. & Sanavi, F. : Guided tissue regeneration in degree II furcation-involved mandibular molars. A clinical study. J Periodontol 1988;15:247-254 https://doi.org/10.1111/j.1600-051X.1988.tb01578.x
  32. Anderegg CR, Marin SJ, Gray JL, Mellonig JT, Gher ME: Clinical Evaluation of the Use of Decalcified Freeze-Dried Bone Allograft With Guided Tissue Regeneration in the Treatment of Molar Furcation Invasions. J Periodontol 1991; 62: 264-268 https://doi.org/10.1902/jop.1991.62.4.264
  33. Caffesse, R. G., Smith, B. A., Duff, B., Morrison, E. C., Merrill, D. & Becker. W.: Class II furcations treated by guided tissue regeneration in humans : Case reports. J Periodontol 1990; 61: 510-514 https://doi.org/10.1902/jop.1990.61.8.510
  34. Wikesjo, U., Nilveus, R. E. : significance of early healing events on periodontal repair. A review. J Periodontol 1992; 63: 158-165 https://doi.org/10.1902/jop.1992.63.3.158
  35. Pitaru S, Tal H, Soldinger M, Azar-Avidan O, Noff M: Collagen Membrane Prevent the Apical Migration of Epithelium During Periodontal Wound Healing. J Periodont Res 1987; 22: 331-333 https://doi.org/10.1111/j.1600-0765.1987.tb01594.x
  36. Black BC, Gher ME, Sandifer JB, Fucini SE, Rechardson AC: Comparative Study of Collagen and e-PTFE Membranes in the Treatment of Human Class II Furcation Defects. J Periodontol 1994; 65: 598-604 https://doi.org/10.1902/jop.1994.65.6.598
  37. Galgut, P. N. : Oxidized cellulose mesh used as a biodegradable barrier membrane in the technique of guided tissue regeneration. A Case report. J Periodontol 1990; 61: 766-768 https://doi.org/10.1902/jop.1990.61.12.766
  38. Fleisher N, Waal HD, Bloom A: Regeneration of Lost Attachment Apparatus in the Dog Using Vicryl Absorbable Mesh(Polyglactic 910). Int J Periodont Rest Dent 1988; 8: 45-55
  39. Caffesse RG, Nasjleti CE, Morrison EC, Sanchez R: Guided Tissue Regeneration: Comparison of Bioabsorbable and Nonbioabsorbable Membranes. Histologic and Histometric Study in Dogs. J Periodontol 1994; 65: 583-591 https://doi.org/10.1902/jop.1994.65.6.583
  40. Lundgren D, Slotte C: Reconstruction of Anatomically Complicated Periodontal Defects Using a Bioresorbable GTR Barrier Supported by Bone Mineral. A 6-Month Follow-Up Study of 6 Cases. J Clin Periodontol 1999; 26: 56-62 https://doi.org/10.1034/j.1600-051X.1999.260110.x
  41. Hurzeler MB, Kohal RJ, Naghshbandi J, Mota LF, Conradt J, Hutmacher D, Caffesse RG: Evaluation of a New Bioresorbable Barrier to Facilitate Guided Bone Regeneration Around Exposed Implant Threads. Int J Oral Maxillofac Surg 1998; 27: 315-320 https://doi.org/10.1016/S0901-5027(05)80623-X
  42. Brooks. D.B. Heiple.K.G. et al : Immunological factors in homogeneous bone transplantation. Ⅳ. The effect of various methods of preparation and irradiation on antigenicity. J. bone Joint Surg 1963; 45: 1617 https://doi.org/10.2106/00004623-196345080-00004
  43. Turner. D.W. and Melloonig.J.T : Antigenicity of freeze-dried bone allograft in periodontal osseous defects. J periodontal Res 1981; 16(1):89-99 https://doi.org/10.1111/j.1600-0765.1981.tb00952.x
  44. Urist, M. R. : Bone formation by autoinduction. Science 1965; 150: 893 https://doi.org/10.1126/science.150.3698.893
  45. Urist, M. R., Silverman B. F. : The bone induction principle. Clin Orthop 1967; 53: 243
  46. Libin, B. M., Ward, H. L. : Decalcified lyophilized bone allografts for use in human periodontal defects. J periodontol 1975; 46: 51 https://doi.org/10.1902/jop.1975.46.1.51
  47. Simon M, Dahlin C : Qualitative and quantitative comparative study on different filling materials used in bone tissue regeneration : A controlled clinical study. Int J periodontics restorative Dent 1994; 14: 198-215
  48. Bowers GM, Chadorff B, Carnevale R, Mellonig JT, Corio R, Emerson J, Stevens J, Romberg E: Histologic Evaluation of New Attachment Apparatus Formation in Humans. Part I. J Periodontol 1989; 60: 664-674 https://doi.org/10.1902/jop.1989.60.12.664
  49. Bowers GM, Chadorff B, Carnevale R, Mellonig JT, Corio R, Emerson J, Stevens J, Romberg E: Histologic Evaluation of New Attachment Apparatus Formation in Humans. Part II. J Periodontol 1989; 60: 675-682 https://doi.org/10.1902/jop.1989.60.12.675
  50. Anderegg CR, Marin SJ, Gray JL, Mellonig JT, Gher ME: Clinical Evaluation of the Use of Decalcified Freeze-Dried Bone Allograft With Guided Tissue Regeneration in the Treatment of Molar Furcation Invasions. J Periodontol 1991; 62: 264-268 https://doi.org/10.1902/jop.1991.62.4.264
  51. Caffesse RG, Nasjleti CE, Plotzke AE, Anderson GB, Morrison EC: Guided Tissue Regeneration and Bone Grafts in the Treatment of Furcation Defects. J Periodontol 1993; 64: 1145-1153 https://doi.org/10.1902/jop.1993.64.11s.1145
  52. Wallace SC, Gellin RG, Miller MC, Mishkin DJ: Guided Tissue Regeneration With and Without Decalcified Freeze-Dried Bone in Mandibular Class II Furcation Invasions. J Periodontol 1994; 65: 244-254 https://doi.org/10.1902/jop.1994.65.3.244
  53. Moon-Il Cho, Wen-Lang Lin : Platelet-Derived Growth Factor-Modulated Guided Tissue Regenerative Therapy. J Periodontol 1995; 66: 522-530 https://doi.org/10.1902/jop.1995.66.6.522
  54. Howell TH, Fiorellini JP and Paquette DW.: A phase I/II clinical trial to evaluation a combination of recombinant human plateletderived growth factor-BB and recombinant human insulin-like growth factor-I in patients with periodontal disease. J Periodontol 1997; 68: 1186-1193 https://doi.org/10.1902/jop.1997.68.12.1186
  55. Tayapongsak P, O'Brien DA, Monteiro CB and Arceo-Diaz LL.: Autologous fibrin adhesive in mandibular reconstruction with particulate cancellous bone and marrow. J Oral Maxillofac Surg 1994; 52: 161-166 https://doi.org/10.1016/0278-2391(94)90401-4
  56. Robert E. Marx, Eric R. : Platelet rich plasma growth factor enhancement for bone grafts. Oral Surg Oral Med Oral Pathol Oral Radiol Indod 1998; 85: 638-646 https://doi.org/10.1016/S1079-2104(98)90029-4
  57. Grondahl H, Grondahl K. : Subtraction radiography for the diagnosis of periodontal bone lesions. Oral Surg 1983; 55: 208. https://doi.org/10.1016/0030-4220(83)90180-9
  58. Grondahl H, Grondahl K, Webber RL : A digital subtraction technique for dental radiography. Oral Surg 1983; 55: 96 https://doi.org/10.1016/0030-4220(83)90314-6
  59. Grondahl H, Grondahl K, Webber RL : A digital subtraction technique for dental radiography. Oral Surg Oral Med Oral Pathol 1988; 65: 490-494 https://doi.org/10.1016/0030-4220(88)90365-9
  60. Ruttimann UE, Webber RL : Volumetry of localized bone lesions by subtraction radiography. J Periodontal Res. 1987; 22: 215-216 https://doi.org/10.1111/j.1600-0765.1987.tb01571.x
  61. Hildebolt CF, Vanier MW : Quantitative evaluation of digital dental radiograph imaging systems. Oral Surg Oral Med Oral Pathol. 1990; 70: 661-668 https://doi.org/10.1016/0030-4220(90)90419-S
  62. Bragger U, Hammerle CHF : Remodelling of periodontal tissues adjacent to sites treated according to the principles of guided tissue regeneration. J Clin Periodontol. 1992; 19: 615-624 https://doi.org/10.1111/j.1600-051X.1992.tb01708.x
  63. Proestkis G., Bratthall G : Guided tissue regeneration in the treatment of infrabony defects on maxillary premolars. A pilot study. J Clin Periodontol. 1992; 19: 766-773 https://doi.org/10.1111/j.1600-051X.1992.tb02168.x
  64. Christgau M., Schmalz G. : Clinical and radiographical split-mouth study on resorbable versus non-resorbable GTR membrane. J Clin Periodontol. 1995; 22: 306-315 https://doi.org/10.1111/j.1600-051X.1995.tb00153.x