The Journal of Korean Physical Therapy

The Korean Society of Physical Therapy (대한물리치료학회)
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Review of Vascular Endothelial Growth Factor

혈관내피성장인자에 관한 고찰

  • Kim, Souk-Boum (Major in Physical Therapy, Dept. of Rehabilitation Science, Graduate School, Taegu University) ;
  • Kim, Dong-Hyun (Department of Occupational Therapy, Sorabol college) ;
  • Song, Ju-Young (Department of Physical Therapy Ulsan College) ;
  • Kim, Jin-Sang (Department of Physical Therapy, College of Rehabilitation Science, Taegu University)
  • 김석범 (대구대학교대학원 재활과학과 물리치료전공) ;
  • 김동현 (서라벌대학 작업치료과) ;
  • 송주영 (울산과학대학 물리치료과) ;
  • 김진상 (대구대학교 재활과학대학 물리치료과)
  • Published : 2002.03.31
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Abstract

Vascular endothelial growth factors(VEGFs) constitute a group of structurally and functionally related growth factor that modulate many important physiological functions of endothelial cells, especially angiogenesis. This paper explain substance, which participate in signaling transduction of VEGF, including Bcl-2, caspase, focal adhesion kinase(FAK), integrin ${\alpha}v{\beta}3$, MAP kinase, nitric oxide(NO)and prostacyclin(PGI2). Physical therapy enhance angiogenesis for repairment of injury which as wound healing, muscle contusion, cerebrovascular disease, rheumatoid arthritis. Therefore this review assist understanding for mechanism of physical therapy as therapeutic angiogenesis.

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