Analytical Science and Technology (분석과학)

The Korean Society of Analytical Sciences (한국분석과학회)
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Analysis of derivatized MX by Gas Chromatography/Mass Spectrometry

GC/MS를 이용한 MX 유도체화 분석법 연구

  • Yoo, Eun-Ah (Department of Chemistry, Sungshin Women's University) ;
  • Park, Do-Yeon (Department of Chemistry, Sungshin Women's University) ;
  • Lee, Hyang-Ki (Department of Chemistry, Sungshin Women's University) ;
  • Myung, Seung-Woon (Doping Control Center, Korea Institute of Science and Technology)
  • 유은아 (성신여자대학교 화학과) ;
  • 박도연 (성신여자대학교 화학과) ;
  • 이향기 (성신여자대학교 화학과) ;
  • 명승운 (한국과학기술연구원 도핑콘트롤센터)
  • Received : 2002.02.19
  • Published : 2002.06.25
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Abstract

AMX is one of extremely high mutagenic compound produced from the reaction of the chlorine and the organic compound during the disinfection of tap water. In this paper, the chemical derivatization of MX with 2% sulfuric acid-methanol, iso-propanol, sec-butanol and n-butanol derivatives for the GC/MS analysis were tested or compared. Limit of detection for the EI and NCI mode were 25 pg and 1.25 pg, respectively. The good linear calibration curve was obtained the range of 25~2500 pg by EI and NCI

MX [3-chloro-4(dichloromethyl)-5-hydroxy-2(5H)-furanone]는 수돗물의 소독을 위해 첨가한 염소와 수중의 유기물이 반응하여 생성되는 강력한 변이원성 물질이다. 본 논문에서는 GC/MS를 이용하여 유도체화 시약인 2% 황산-methanol, iso-propanol, sec-butanol, n-butanol을 이용하여 MX의 유도체화를 비교하였으며, 이온화 방법으로 EI 와 NCI를 비교한 결과, NCI 방법에서 검출 한계가 1.25 pg으로 EI 방법에서는 25 pg이였으며, 25~2500 pg 범위에서 직선성을 나타내었다.

Keywords

References

  1. J. J. Rook, Water Treat. Exam., 23, 284(1974)
  2. T. A. Bellar, J. J. Lichtenberg and R. C. Kroner, J. AWWA, 66, 703(1974)
  3. International Agency for Research on cancer, chlorinated Drinking-Water, Chlorination By-Products ; Some Other Halogenated Compounds; Cobalt and Cobalt Compounds, IARC Monogr. Eval. Carcinog. Risks Humans, 52, International Agency for Research on Cancer, Lyon, France, 1991
  4. M. Koivusalo, J.J. Jaakkola, T. Vartiainen, T. Hakulinen, S. Karjalainen, E. Pukkala and J. Tuomisto, Drinking water mutagenicity and gastrointestinal and urinary tract cancers ; an ecological study in Finland, Am. J. Public Health, 84, 1033-1039(1994)
  5. J. Hemming, B. Holmbom, M. Reuranen and L. Kronberg, Chemosphere, 15, 549-55(1986)
  6. B. H. Holmbom, et al., Tappi, 64(3), 172-174(1981)
  7. H. Horth, AQUA, 38(2), 80-100(1989)
  8. Meier, J. R. Knohl, R. B. Coleman, W. E. Ringhand, H. P. Munch, J. W. Kaylor, W. H. Streicher and R. P. Kopfler, Mutat. Res., 189, 363-373(1987)
  9. H. Horth, J. Fr. Hydrol., 21, 135(1990)
  10. Noriyuki Suzuki and Junko Nakanishi, Chemosphere, 21(3), 387-392(1990)
  11. Zou Huixian, Xu Xu, Zhang Jinqi and Zhu Zhen, Chemosphere, 30(12), 2219-2225(1995)
  12. T. Vartiainen, K. Heiskanen, and S. Lotjonen, Fresnius, J. Anal. Chem., 340, 230-233(1991)
  13. W. E. Coleman, et. al., Environ. Sci. Technol., 18, 674-681(1984)
  14. L. Kronberg and R. Franzen, Environ. Sci. Technol., 27, 1817-1818 (1993)
  15. M. J. Charles, Gong Chen, R. Kannlgantl and G. D. Marbury, Environ. Sci. Technol., 26, 1030-1035(1992)
  16. J. Nawrocki, P. Andrzejewski, L. Kronberg and H. Jelen, J. Chromatogr. A., 790, 242-250(1997)
  17. S. Ogawa, H. Kita, Y. Hanasak, S. Fukui and H. Kami, J. Chromarogr. 643, 221-226(1993)
  18. J. Nawrocki, P. Andrzejewski, J. Henryk and Erwin Wasowicz., Wat. Res., 35(8), 1891-1896(2001)