Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Effects of Bojungchiseup-tang on Renal Expression of Water Channels, Na, K-ATPase and Nitric Oxide Synthase in Rats

보중치습탕의 백서 신장 수분채널, Na, K-ATPase, 산화질소 합성효소 발현에 미치는 영향

  • Kang Dae Gill (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Kim Jang Giun (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Kim Bok Hae (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Cho Dong Ki (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Sohn Eun Jin (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Ryu Do Gon (College of Oriental Medicine, Wonkwang University) ;
  • Lee Ho Sub (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University)
  • 강대길 (원광대학교 한의학전문대학원 한약자원개발학과) ;
  • 김종균 (원광대학교 한의학전문대학원 한약자원개발학과) ;
  • 김복해 (원광대학교 한의학전문대학원 한약자원개발학과) ;
  • 조동기 (원광대학교 한의학전문대학원 한약자원개발학과) ;
  • 손은진 (원광대학교 한의학전문대학원 한약자원개발학과) ;
  • 류도곤 (원광대학교 한의과대학) ;
  • 이호섭 (원광대학교 한의학전문대학원 한약자원개발학과)
  • Published : 2002.02.01
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Abstract

The present study was examined the effects of Bojungchiseup-tang water extract on the renal expression of renal function regulatory proteins including aquaporin 2 (AQP 2), aquaporin 3 (AQP 3), Na, K-ATPase α1 subunit, endothelial nitric oxide synthase (ecNOS), and inducible nitric oxide synthase (iNOS) in rats. The renal expression of AQP 3 was attenuated in rats administered with Bojungchiseup-tang water extract without altered expression of AQP 2, while ecNOS was up-regualted. Oral administration of Bojungchiseup-tang water extract (40 ㎕/100 g) also attenuated the renal expression of Na, K-ATPase α1-subunit and iNOS protein. These results suggest that the diuretic and natriuretic effects of Bojungchiseup-tang maybe causely related with a decreased expression of AQP 3 and increased expression of ecNOS.

Keywords

References

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