Inhibitory Effects of Hwao-tang on the Atherosclerosis and the Venous Thrombosis

  • Hong Mun Yoob (Department of Diagnostics, College of Oriental Medicine. Dongguk University) ;
  • Choi Dall Yoong (Department of Pathology, College of Oriental Medicine. Dongguk University) ;
  • Kim Cherl Ho (Department of Biochemistry, College of Oriental Medicine. Dongguk University) ;
  • Kim Beob Jin (Department of Diagnostics, College of Oriental Medicine. Dongguk University) ;
  • Kim Han Geu (Department of Diagnostics, College of Oriental Medicine. Dongguk University) ;
  • Ahan Jong Chan (Department of Diagnostics, College of Oriental Medicine. Dongguk University) ;
  • Lee Soo Kyung (Department of Diagnostics, College of Oriental Medicine. Dongguk University) ;
  • Chung Tae Wook (Department of Diagnostics, College of Oriental Medicine. Dongguk University) ;
  • Park Won Hwan (Department of Diagnostics, College of Oriental Medicine. Dongguk University)
  • Published : 2002.04.01


The inhibitory effects of the traditional herbal medicine Hwao-tang on the progression of the atherosclerotic lesions were studied using the spontaneous familial hypercholesterolemia (FH) model, Kurosawa and Kusanagi-hypercholesterolemic (KHC) rabbits. Hwao-tang is activate blood circulation, vital energy and regulate menstruation, etc. Nowadays, Hwao-tang is mainly used for the treatment of inflammation, hyperlipemia and arteriosclerosis. However, pharmacological mechanisms of Hwao-tang on lipid metabolism and atherosclerosis formation are poorly understood. We have investigated the pharmacological effects of Hwao-tang on hypercholesterolemia and atherosclerosis using a spontaneous experimental model. In conclusion, the protection of extracts of HOT and its herbs on the ischemic infarction induced artificially might be related to their inhibitory effects on DIC, platelet coagulation and thrombic action. These suggest that Hwao-tang has inhibitory effects on the development of atheromatous plaque formation in spontaneous FH model rabbits. It is possible that the anti oxidative effects of Hwao-tang on LDL led to the beneficial effects observed in this study.


  1. Thesis of master The effect of Daejowhan on cerebral and thalamic atrophy following middle cerebral artery occulsion in rats. Cho, G-S.
  2. Clinic of Traditional Chinese Medicine (Ⅰ) Zhang Enqin
  3. A Study of the influence of both of Shunqidaotantang and Huayutang on thrombosis, contusion-hyperemia and hyperlipidemia Won-Hwan Park
  4. Chinese-English manual of common-used prescriptions in TCM Ou Ming
  5. Laboratory Animal Science v.45 New mutant rabbit strain with hypercho -lesterolemia and atherosclerotic lesions produced by serial inbreeding Kurosawa, T.;Kisanagi, M.;Yamasaki, Y.;Senga, Y.;Yamamoto, T.
  6. Proc. Natl. Acad. Sci. v.84 Probucol prevents the progression of atheroclerosis in Watanabe heritable hyperlipidemic rabbit, an animal model for familial hypercholesteromoa. Kita, T.;Nagano, Y.;Yokode, M.;Ishii, K.;Kume, N.;Ooshima, A.;Yoshida, H.;Kawai, C.
  7. The Lancet v.344 Inhibition of oxidation of low-density lipoprotein with red wine. Kondo, K.;Matsumoto, A.;Kurata, H.;Tanahashi, H.;Koda, H.;Amachi, T.;Itakura, H.
  8. Shoyakugaku Zasshi v.38 Studies on Moutan Cortex VIII: Inhibitory effects on the intravascular coagulation. Kubo, M.;Matsuda, H.;Matsuda R.
  9. Shoyakugaku Zasshi v.41 Effect of Crocus (Crocus sativus Linne, Iridaceae) on blood coagulation and fibrinolysis. Nishio, T.;Okugawa, H.;Kato, A.;Hashimoto, Y.;Matsumoto, K.;Fujioka, A.
  10. Biochem. Pharmacology v.32 Triphenyltin fluoide in vitro inhibition of rabbit platelet collagen-induced aggregation and ATP secretion and blockage of arachidonic acid mobilization from membrane phospholipids. Manabe, S.;Wada, O.;Matsui, H.;Takeda, M.;Kobayashi, N.;Maekawa, T.
  11. Planta Med. v.57 Platelet aggregation inhibitors from the seeds of Swietenia mahagoni: inhibition of in vitro and in vivo platelet-activating factor-induced effects of tetranortriperpenoids related to swietenine and swietenolide Ekimoto, H.;Irie, Y.;Araki, Y.;Han, G.Q.;Kadota, S.;Kikuchi, T.
  12. Arch. Biochem. Biophys. v.40 The fibrin plate method for estimating fibrinolytic activity. Astrup, T.;Mullertz, S.
  13. 臨床脂質學, 金辰圭
  14. 成人病 老人病學 徐順圭
  15. Patology The korean society of pathology
  16. Pathology(in explaination of figure) A.D.T.Govan;P.S. Macfarlane;R.Callander;J. D., Lee
  17. Textbook of Medical physiology 7th ed. Guytion AC
  18. Cecil Textbook of Medicine 19th ed. Wyngaarden, J.B.(et al)
  19. The Journal of Oriental Medical Pathology v.4 no.1 Bibliographic Study on Wool(鬱), Dam(痰) and Ue(瘀) Syndromes Byung Hun Jeon
  20. YimSangBonChoHak Min Gyo Shin
  21. 牧丹皮の硏究 v.8 抗血栓形成作用について 久保道德;松田秀秋;松田玲子
  22. Jpn. Circulation Journal v.60 Recombinant tissue plasminogen activator prevents intimal hyperplasia after balloon angioplasty in hypercholesterolemic rabbits Kanamasa, K.;Ishida, N.;Kato, H.;Sakamoto, S.;Nakabayashi, T.;Otani, N.;Ishikawa, K.;Katori, R.
  23. Proc. Natl. Acad. Sci. v.76 A binding site on macrophages that mediates the uptake and degradation of acethylated low density lipoprotein, producing massive cholesterol deposition. Goldstein, J.L.;HO, Y.K.;Basu, S.K.;Brown, M.S.
  24. New England Journal of Medicine v.320 Modifications of low density lipoprotein that increase it atherogenicity. Steinberg, D.;Parthasarathy, S.;Carew, T.E.;Khoo, J.C.;Witztum, J.L.
  25. The Lancet v.339 Autoantibody against oxidized LDL and progression of carotid atherosclerosis. Salonen, J.T.;Yla-Herttuala, S.;Yamamoto, R.;Butler, S.;Korpela, H.;Salonen, R.;Nyyssonen, K.;Palinkski, W.;Witztum, J.L.
  26. British Medical Journal v.314 Autooxidant state and mortality from coronary heart disease in Lithuanian and Swedish men: concomitant cross sectional study of men aged 50. Kristenson, M.;ZiedEn, B.;KucinskienI, Z.;Elinder, L.S.;Bergdahl, B.;Elwing, B.;Abaravicius, A.;Razinkovienl, L.;Calkauskas, H.;Olsson, A.G.
  27. Shoyakugaku Zasshi v.38 Studies on Scutellaria Radix (VIII) Anti-thrombic actions of 70% methanolic extract and various fractions from Scutellariae Radix Kubo, M.;Matsuda, H.