Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Study on Antitumor and Immunomodulatory Effects of Cambodian Phellinus linteus

캄보디안 상황버섯의 항암 및 면역조절작용에 대한 연구

  • Lee Hyo Jeong (Graduate School of East-West Medical Science, Kyunghee University) ;
  • Park Jung Min (Graduate School of East-West Medical Science, Kyunghee University) ;
  • Song Gyu Yong (Graduate School of East-West Medical Science, Kyunghee University) ;
  • Kang Kyung Sun (Department of Veterinary Public Health, College of Veterinary Medicine and School of Agricultural Biotechnology, Seoul National University) ;
  • Kim Sung Hoon (Graduate School of East-West Medical Science, Kyunghee University)
  • 이효정 (경희대학교 동서의학대학원) ;
  • 박정민 (경희대학교 동서의학대학원) ;
  • 송규용 (경희대학교 동서의학대학원) ;
  • 강경선 (서울대학교 수의과대학) ;
  • 김성훈 (경희대학교 동서의학대학원)
  • Published : 2002.04.01
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Abstract

Phellinus Iinteus from Cambodia was confirmed to have a homologous DNA sequencec to Phellinus Iinteus. Antitumor and immunomodulatory activities were evaluated with aquous extract of Cambodian Phellinus Iinteus(CPL). CPL didn't show any significant cytotoxicity on HT1080, Sarcoma 180 and B16BL6, whereas it inhibited the relaxation of DNA topoisomerase I from the concentration of 250ug/ml. In the pulmonary colonization assay it inhibited pulmonary metastasis by B16BL6 in C57BL6 mice to 36%, 36.9% and 55.5% at various doses of 2 mg, 20 mg and 50 mg. From FACS analysis with splenocytes pretreated with CPL, it significantly increased lymphoblast and induced production of IL-2. These results indicate Cambodian Phellinus Iinteus has antitumor and immunomodulatory activities still suggesting more study on its mechanism and effective compound in detail.

Keywords

References

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