Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Study on the Effect of Sopungbosim-tang on Hypertension, Thrombosis and Brain damage

소풍보심탕이 고혈압, 혈전 및 뇌진탕에 미치는 영향

  • Bae Kyung IL (Department of Oriental internal medicine, College of Oriental Medicine, Taejeon University) ;
  • Kim Dang Hee (Department of Oriental Pathology. College of Oriental Medicine, Taejeon University) ;
  • Lee Yang Gu (Department of Oriental internal medicine, College of Oriental Medicine, Taejeon University) ;
  • Kim Yoon Sik (Department of Oriental internal medicine, College of Oriental Medicine, Taejeon University) ;
  • Seol In Chan (Department of Oriental internal medicine, College of Oriental Medicine, Taejeon University)
  • 배경일 (대전대학교 한의과대학 내과학교실) ;
  • 김동희 (대전대학교 한의과대학 병리학교실) ;
  • 이용구 (대전대학교 한의과대학 내과학교실) ;
  • 김윤식 (대전대학교 한의과대학 내과학교실) ;
  • 설인찬 (대전대학교 한의과대학 내과학교실)
  • Published : 2002.04.01
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Abstract

This studt was investigated to prove the effect of SPBST on the hypertension, the thrombosis and the brain damage. The results were as follows; 1. SPBST affected the htpertension as adepressant, but insignificant. 2. SPBST decreased significantly dopamine, aldosterone but ineffective on the epinephrine, norepinephrine and renin activity. 3. SPBST increased the NO product but insignificant. 4. SPBST had a death suppression effect by 50% in pulmonary thrombosis inducement experiment and activated slightly on the fibrinolytic activity. 5. SPBST suppressed significantly platelet diminution and prolonged insignificantly PT and APTT. 6. On the measure of the blood flow rate induced by the thrombus, in vivo SPBST accelerated the blood flow rate, in vitro insignificant. 7. SPBST had no toxicity on the PC12 cell and B103 cell induced by amyloid β protein (-35) and a protective effect, in proportion to the density. 8. SPBST decreased significantly coma duration time in a Infatal dose of KCN and showed 50% of survival rate in a fatal dose. 9. SPBST decreased significantly ischemic area and edema incited by the MCA blood flow block. These results indicate that SPBST can be used in hypertension, the thrombosis, the brain damage, the ischemic cerebral infarction and the acute stage of the brain damage. Further study will be needed about the functional mechanism and etc.

Keywords

References

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