Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Effect of Mixture of Gastrodiae rhizoma on Blood Amelioration in High Cholesterol-diet Rats

고콜레스테롤 식이 랫드에서 천마혼합액의 혈액개선 효과

  • Lee Young Sun (Efficacy and Safety Research Center for Traditional Oriental Medicines. Kyungsan University) ;
  • Han Ok Kyung (Efficacy and Safety Research Center for Traditional Oriental Medicines. Kyungsan University) ;
  • Jean Tae Won (Efficacy and Safety Research Center for Traditional Oriental Medicines. Kyungsan University) ;
  • Lee Eun Sil (Efficacy and Safety Research Center for Traditional Oriental Medicines. Kyungsan University) ;
  • Kim Kwang Joong (Department Physiology, College of Oriental Medicine, Kyungsan University) ;
  • Bae Jae Chil (Cheonma Natural Food) ;
  • Kim Hyo Jung (Efficacy and Safety Research Center for Traditional Oriental Medicines. Kyungsan University, Department Physiology, College of Oriental Medicine, Kyungsan University)
  • 이영선 ((재)경북테크노파크 경산대학교 한방생명자원 특화센터 효능검증원) ;
  • 한옥경 ((재)경북테크노파크 경산대학교 한방생명자원 특화센터 효능검증원) ;
  • 전태원 ((재)경북테크노파크 경산대학교 한방생명자원 특화센터 효능검증원) ;
  • 이은실 ((재)경북테크노파크 경산대학교 한방생명자원 특화센터 효능검증원) ;
  • 김광중 (경산대학교 한의과대학 한방생리학교실) ;
  • 배재칠 (천마자연식품) ;
  • 김효정 ((재)경북테크노파크 경산대학교 한방생명자원 특화센터 효능검증원, 경산대학교 한의과대학 한방생리학교실)
  • Published : 2002.04.01
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Abstract

This study was carried out to investigate the effect of mixture of Gastrodiae rhizoma (GM) on blood amelioration in high cholesterol-diet rats. Sprague-Dawley male rats were randomly assigned to one normal diet and three high cholesterol-diet groups which contained 1 % (w/w) cholesterol diet. The groups of high cholesterol-diet were classified to control (high cholesterol-diet only), GM-1 (high cholesterol-diet and GM) and ST-1 (high cholesterol-diet and Statin drug). The body and organs weight were not significantly changed among the tested groups. Contents of serum total cholesterol and LDL-cholesterol were significantly increased in cholesterol-diet groups compared with normal diet group but significantly decreased in the group of GM-1. Morphology of red blood cell in GM-1 group was similar to normal diet group but the control group had many crystals of cholesterol. Hepatic xanthine oxidase activity in the rats of high cholesterol-diet was decreased up to the levels of normal diet group according to oral administration of GM. The results of the present study demonstrate that the orally injection of GM can ameliorate the status of total cholesterol and LDL-cholesterol, and repress xanthine oxidase in liver in high cholesterol-diet rats. These finding suggest that GM is expected to be an effective tea for the blood amelioration in high cholesterol-diet rats.

Keywords

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