Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Inhibitory Effects of Silsosangami on the Platelet Aggregation

  • Kim Jong Soo (Department of Diagnostics, College of Oriental Medicine, Dongguk University) ;
  • Kim Beob Jin (Department of Diagnostics, College of Oriental Medicine, Dongguk University) ;
  • Kim Han Geu (Department of Diagnostics, College of Oriental Medicine, Dongguk University) ;
  • Ahan Jong Chan (Department of Diagnostics, College of Oriental Medicine, Dongguk University) ;
  • Lee Soo Kyung (Department of Diagnostics, College of Oriental Medicine, Dongguk University) ;
  • Chung Tae Wook (Department of Diagnostics, College of Oriental Medicine, Dongguk University) ;
  • Choi Dall Yeong (Department of Pathology, College of Oriental Medicine, Dongguk University) ;
  • Kim Cheri Ho (Department of Biochemistry, College of Oriental Medicine, Dongguk University) ;
  • Park Won Hwan (Department of Diagnostics, College of Oriental Medicine, Dongguk University)
  • Published : 2002.08.01
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Abstract

The thrombosis importantly came to the front as the risk factor of these circulation system's disease. SilsoSanGami(SSG) was used for investigating the inhibitory effect on platelet-activating factor-induced platelet aggregation about drugs that used to improvement various symptoms created by the thrombosis in oriental medicine. In this study, the water-extracted SSG was investigated for its possible antithrombotic action on platelets. The antithrombotic activity of water-extracted SSG was deduced from its ability to suppress platelet aggregation, ATP-exocytosis, and the generation of prostaglandin E₂ and thromboxane A₂ by human platelets, stimulated with arachidonic acid. Water-extracted SSG dose-dependently suppressed the aggregation of human platelets, the release of endogenous ATP, and the formation of PGE₂ and TXB₂, both the latter usually detected to estimate the activity of COX and TXS, respectively. Since the IC/sub 50/ values necessary to inhibit COX (115 ㎍/㎖ SSG) and TXS(74 ㎍/㎖ SSG) were in the same range, inhibition of COX is suggested to be the primary target of water-extracted SSG, thus suppressing the formation of PGE₂ which is metabolized by TXS to TXA₂. We considerated that SSG has practical applicational value of clinical trial in the thrombosis caused by platelet aggregation.

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References

  1. 東醫病理學會誌 v.4 鬱證 痰證 瘀證에 關한 文獻的 考察 田炳薰
  2. 成人病 老人病學 徐順圭
  3. 病理學 대한병리학회
  4. 그림으로 설명한 병리학 이중달(역);A.D.T.Govan;P.S. Macfarlane;R.Callander(원저)
  5. Textbook of Medical physiology Guytion AC,
  6. 臨床本草學 신민교
  7. 牧丹皮の硏究 v.8 抗血栓形成作用について 久保道德;松田秀秋;松田玲子
  8. Huo Xue Huo Yu yanjiu xinbian Jiang Chun Hua,
  9. Thesis of master, Dongguk University The effect of Daejowhan on cerebral and thalamic atrophy following middle cerebral artery occulsion in rats. Cho, G-S.
  10. Ann. Rev. Biochem. v.55 Hanahan, D. J.
  11. Pharmacol. Rev. v.39 Braquet, P.;Touqui, I.;Shen, T. Y.;Vargaftig, B. B.
  12. Trends Pharmacol. Sci. v.7 Braquet, E.;Godfroid, J.J.
  13. Proc. Natl. Acad. Sci. USA v.82 Shen, T.Y.;Hwang, S.B.;Chang, M.N.;Doebber, T.W.;Lam, M.H.;Wu, M.S.;Wang, X.H.;Li, R. J.
  14. Tetrahedron Lett. v.29 Corey, E.H.;Chen, C.P.;Parry, M.J.
  15. Phytotherapy Resear v.2 Hosford, D.;Mencia-Hueta, J.M;Page, C.; Braquet, P.
  16. Planta Med. v.57 Platelate aggregation inhibitors from the seeds of Swietenia mahagoni: inhibition of in vitro and in vivo platlet- activating factor-induced effects of tetranortriperpenoids related to swietenine and swietenolide Ekimoto, H.;Irie, Y.;Araki, Y.;Han, G.Q.;Kadota, S.;Kikuchi, T.
  17. Prostaglandins v.30 Young, J.M.;Maloney, P. J.;Jubb, S. N.;Clark, J.S.,
  18. J. Clin. Pathol. v.15 O'Brien, J. R.
  19. J. Med. Chem. v.28 Kato, K.;Ohkawa, S.;Terao, S.;Terashita, Z.;Nishikawa, K.,
  20. Physiol. Rev. v.69 Siess, W.
  21. Pharmacol. Exp. Ther. v.228 Parise, L. V.;Venton, D. L.;LeBreton, G.C.
  22. Am. J. Physiol. v.249 Brace, L.D.;Venton, D.L.;LeBreton, G.C.
  23. Planta Medica v.63 Antithrombotic action of the Kava Pyrone (+)-Kavain prepared from Piper methysticum on human platelets. Gleitz, J.;Beile, A.;Wilkens, P.;Ameri, A.;Peters, T.
  24. Medical Res. Review v.5 Snyder, F.
  25. New Horizones in Platelet Activating Factor Research Nigam, S.;Shipka, S.
  26. Proc. Natl. Acad. Sci. USA v.90 Weissman, D.;Poli, G.;Bousseau, A.;Fauchi, A. S.
  27. Biochem. Biophys. Res. Comm. v.176 Yamada, T.;Tommioka, K.;Horie, M.;Sakurai, Y.;Nagaoka, H.;Mase, T.
  28. 惠和醫學 v.5 中風治療에 있어서 活血化瘀法에 對한 文獻的 考察 임준식
  29. Cecil Textbook of Medicine Wyngaarden, J.B.(et al)