Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Immunoreactive Cells of Gastrin and Histamine and the Lymphocytes of Spleen and Thymus in Mice Stomach

화담청화탕 열탕액이 생쥐 위의 Gastrin, Histamine 면역반응세포와 비장, 흉선의 Lymphocytes에 미치는 영향

  • Oh In Kyun (Department of Oriental Physiology, Woosuk University) ;
  • Choi Seung Youl (Department of Oriental Pathology, Woosuk University) ;
  • Ko Byung Moon (Anatomy and College of Oriental Medicine, Woosuk University) ;
  • Lee Kwang Gyu (Department of Oriental Pathology, Woosuk University) ;
  • Oh Chan Ho (Division of Biotechnology, Woosuk University) ;
  • Lee Chang Hyun (Anatomy and College of Oriental Medicine, Woosuk University)
  • 오인균 (우석대학교 한의과대학 생리학교실) ;
  • 최승열 (우석대학교 한의과대학 병리학교실) ;
  • 고병문 (우석대학교 한의과대학 해부학교실) ;
  • 이광규 (우석대학교 한의과대학 병리학교실) ;
  • 오찬호 (우석대학교 생물공학과) ;
  • 이창현 (우석대학교 한의과대학 해부학교실)
  • Published : 2002.08.01
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Abstract

To examine effects of Whadamcheongwha-tang(WDCWT) extract, the mice investigated the gastrin and histamine secreting cells of the stomach by immunohistochemical method, and the lymphocytes of the spleen and thymus by flow cytometry after the oral administration of WDCWT extract(0.2ml/day) and omeprazole (1mg/day) for 7, 14 and 21 days. The result are as follows; 1. When WDCWT extract was administrated for 7 days, in result, gastrin secreting cells were unchanged. When omeprazole was administrated for 7 and 14 days, gastrin secreting cells were slightly increased than that of normal control group. When WDCWT extract was administrated for 21 days, in result, gastrin secreting cells were significantly increased 1.9 times than that of normal control group. When omeprazole was administrated for 21 days, gastrin secreting cells were increased 1.96 times than that of normal control group. 2. When WDCWT extract and omeprazole were administrated for 7 days, in result, histamine secreting cells were unchanged. When WDCWT extract was administrated for 21 days, in result, histamine secreting cells were significantly increased 1.9 times more than that of normal control group. When omeprazole was administrated for 21 days, in result, histamine secreting cells were increased 2.1 times compared with normal control group. 3. When WDCWT extract administrated for 7, 14 and 21 days, in result, splenic Band T lymphocytes, especially T/sub H/ lymphocytes were significantly increased compared with normal control group, and thymic T/sub H/ lymphocytes were also increased in WDCWT administrated group for 14 days. The results suggest that WDCWT extract inhibit a gastric acid secretion in mice stomach, and is useful in the treatment of the hyperacidity and gastric ulcer.

Keywords

References

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