Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Study of Repair Effect of Anti-Alzheimer on $\beta$APP Overexpression In Neuroblastoma cell line by Ramulus et Uncus Uncariae

조구등이 $\beta$APP 과발현 인간 신경아세포암에서의 항치매 효과에 관한 연구

  • Kim Sang Ho (Department of Oriental Neuropsychiatry Medicine, College of Oriental Medicine, Wonkwang University) ;
  • Kang Won Hyung (Department of Oriental Neuropsychiatry Medicine, College of Oriental Medicine, Wonkwang University) ;
  • Lyu Yeoung Su (Department of Oriental Neuropsychiatry Medicine, College of Oriental Medicine, Wonkwang University)
  • 김상호 (원광대학교 한의과대학 한방심경정신과학교실) ;
  • 강형원 (원광대학교 한의과대학 한방심경정신과학교실) ;
  • 유영수 (원광대학교 한의과대학 한방심경정신과학교실)
  • Published : 2002.10.01
Download PDF
⟨ Previous Next ⟩

Abstract

Ramulus et Uncus Uncariae (JGD) has sweet in flavour and slightly cold in property, acting on the liver and pericardium channels. This drug was described in a medical classic as having the ability to remove 'heat', check hyperfunction of the liver and relieve dizziness, tremors, and convulsions, and subdue 'endogenous wind'. So this study was estimated to check the anti-neuropathological effect of JGD on the Alzheimer in βAPP overexpression in neuroblastoma cell line and JGD extract was showed significantly anti-alzheimer effects (50 and 100 μg/㎖ of JGD extracts) compared with control group. Ramulus et Uncus Uncariae has anti-alzheimer effects on the βAPP overexpression in neuroblastoma cell line. So we expect that Ramulus et Uncus Uncariae may be used as a drug for neurodegenerative disease, such as stroke, Alzheimer's disease (AD). These results indicate that Ramulus et Uncus Uncariae possess strong inhibitory effect in the nervous system of apoptosis and repair effect against the degeneration of Neuroblastoma cells by βAPP expression.

Keywords

References

  1. 景岳全書 張介賓
  2. ICD-10 정신 및 행동장애 분류 李符永(譯)
  3. 동의정신의학 김지혁;황의완
  4. Pharmacotherapy; apathophysiologic approach Alzheimer's Disease Andrea Eggert;M. Lynn Crismon;Larry Ereshefsky;Dipiro J. T.(et al.Ed.)
  5. Brain Res v.593 no.2 Senile plaques in cerebral amyloid angiopathy show accumulation of amyloid precursorprotein without cytoskeletal abnormailties Tabaton M;Cammarata S;Mandybur T;Richy P;Kawai M;Perry C;Gambetti P
  6. Acta Neuropathol v.84 no.6 Immunocytochemistry of neurofibrillary tangles with antibodies to subregions of tauprotein; identification of hidden and cleaved tau epitopes and a new phosphorylation site Dickson D. W.;Ksiezak-Reding H;Liu WK Davies P;Crowe A;Yen S. H.
  7. Brain v.114 The decline of working memory in Alzheimer's disease, A longitudinal study. Baddeley A. D.;Bressi S.;Della Sala S.;Logie R.;Spinnler H.
  8. J Neurogenet v.12 no.1 Somatic mutation analysis of the APP and Presenilin 1 and 2 genes in Alzheimers disease brain Reznik-Wolf H.;Machado J.;Haroutuian V.;DeMacro L.;Walter G. F.;Coldman S.;Davidson M.; Johnston J. A.;LanHelt L.;Dani S. U.;Friedman E.
  9. 遠志에 의한 腦 星狀細胞로부터炎症性 細胞活性物質 分泌의 抑制 效果에 關한 硏究 v.10 no.1 황시영;강형원;유영수
  10. Biolchem v.276 no.31 The amyloidogenic pathway of amyloid precursor protein(APP) is independent of its cleavage by caspases Soriano S;Lu DC;Chandra S;Pietrzik CU;Koo EH
  11. FASEB J v.14 no.11 Carboxyl-terminal fragment of Alzheimer's APP destabilizes calcium homeostasis and renders neuronal cells vulnerable to excitotoxicity Kim HS;Park CH;Cha SH;Lee JH;Lee S;Kim Y;Rah JC;Jeong SJ;Suh YH.
  12. Neuron v.10 Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the $\beta$-amyloid precursor protein. Mattson MP;Cheng B;Culwell AR(et al.)
  13. 原色臨床本草擧 辛民敎
  14. 대한한의학회지 제8권제1호 附錄 본초분과학회지 v.2 no.1 釣鉤藤에 관한 支獻的 硏究 李盛雨;廬昇鉉
  15. 本草綱目 第二冊 明 ·李時珍
  16. 대한한방내과학회지 v.13 no.2 老人性 痴?에 대한 文獻的 考寮 金覽兒
  17. 東醫神經精神學會誌 v.7 no.1 치매에 對한 文獻的 考寮 鄭仁哲;李相龍
  18. 大韓韓方內科學會誌 v.16 no.1 치매에 關한 東西醫學的 比較 考寮 李東垣(外)
  19. 大韓韓醫學會誌 v.13 no.2 老人性 치매에 關한 體質醫學的 硏究 裵旿星
  20. 大韓韓方內科學會誌 v.19 no.1 치매에 관한 최근의 연구 동향 나창수(외)
  21. 동의신경정신과학학회지 v.10 no.1 Vascular Dementia에 관한 한의학적 임상연구 현경철;김종우;황의완
  22. 東醫神經精神學會誌 v.7 no.1 치매에 對한 韓醫學的 臨床硏究 황의완(외)
  23. 원광대 대학원 학위논문 침구자극이 치매와 관련된 melatonin 분비와 SOD합성에 미치는 영향 서정럴
  24. 동의신경정신과학회지 v.10 no.1 麝香蘇合元이 Alzheimer's disease모델 白鼠의 학습과 기억에 미치는 영향 황의찬
  25. 동의신경정신과학회지 v.11 no.2 익정지황탕이 치매병태모델에 미치는 영향 최병만;이상룡
  26. 東醫神經精神學會誌 v.9 no.1 天門冬에 의한 腦神經細胞로부터 炎症性細胞活性物質 分泌의 抑制 效栗 강형원;유영수
  27. Am J Hum Genet. The Amyloid Precursor Protein Locus and Very-Late-Onset Alzheimer Disease. Olson JM;Coddard KA;Dudek DM.
  28. 釜山大學校 藥學硏究誌 v.29 no.2 녹차로부터 분리된 Epicatechin 3-O-Callate의 항산화작용 기전에 관한 연구 백봉숙(외)
  29. J. Med. Plant Research v.49 K. Endo;Y. Oshima;H. Kikuchi;Y. Kodhihara;H. Hikino
  30. Lloydia v.41 no.6 J. D. Phillipson;S. R. Hemingway
  31. 생약학회지 v.104 조구등(釣鉤薦) 성분의 항경련 효과 I;에틸아세테이트 분획의 항경련 효과 김동영
  32. 경성대 대학원 학위논문(박사) 조구등 추출물의 항경련 효과 기전 및 활성성분의분리 김동영
  33. 서울대 대학원 학위논문(박사) 조구등의 phospholipase C$\gamma$ 저해 성분과 그 항암효과 이지숙