Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Effect of Bojunglkgi-tang on the Specific Immune Response in BALB/c Mice

보중익기탕이 생쥐의 특이적 면역반응에 미치는 영향

  • Eun Jae Soon (Department of Pharmacy, Woosuk University) ;
  • Chai Hoon (Department of Pharmacy, Woosuk University) ;
  • Song Jung Ma (College of Oriental Medicine, Woosuk University)
  • Published : 2002.10.01
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Abstract

The purpose of this research was to investigate the effects of Bojunglkgi-tang water extract (BE) on the specific immune response in BALB/c mice. When BE (500mg/kg) was administerd p.o. once a day for 7 days to BALB/c mice, the cell viability of splenocytes was increased and DNA fragmentation of splenocytes was decreased. But, BE did not affect the cell viability and DNA fragmentation of thymocytes. Also, BE increased the population of Thy1/sup +/ cells and TH cells in splenocytes. In addition, BE increased the production of γ -interferon from splenocytes. These results suggest that BE enhances the specific immune response via activation of TH1 cells in splenocytes.

Keywords

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