Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Effects of Extracts of Folium Mori on Cadmium Aerosol Inhalation Toxicity in Rats

상엽 추출물이 흰쥐의 카드뮴 에어로졸 흡입독성에 미치는 영향

  • Park Jae Soo (Department of Oriental Medicine, Graduate School of Wonkwang University) ;
  • Jeung Jae Yeal (The Third Medicine, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Lee Taek Jun (Department of Oriental Medicine, Graduate School of Wonkwang University) ;
  • Kang Sung Ho (The Third Medicine, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Song Young Sun (The Third Medicine, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Lee Ki Nam (The Third Medicine, Professional Graduate School of Oriental Medicine, Wonkwang University)
  • 박재수 (원광대학교 대학원 한의학과) ;
  • 정재열 (원광대학교 한의학전문대학원 제3의학과) ;
  • 이택준 (원광대학교 대학원 한의학과) ;
  • 강성호 (원광대학교 한의학전문대학원 제3의학과) ;
  • 송용선 (원광대학교 한의학전문대학원 제3의학과) ;
  • 이기남 (원광대학교 한의학전문대학원 제3의학과)
  • Published : 2002.12.01
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Abstract

To experiment the effects between cadmium inhalation toxicity and extracts of Folium Mori, rat inhalation exposure groups were exposed to cadmium aerosol in air by whole-body inhalation exposure for 6 hours/day, 5 days/week, and 4 weeks. Cadmium concentration in the air of cadmium aerosol was 1.02㎎/㎥ and mass median diameter(MMD) was 1.40μm. Intraperitoneal injection of extracts of Folium Mori to inhalation exposure groups was done for 4 weeks and the results were as follows: The highest body weight gain for 4 weeks and food intake per day were 126.39g/4 weeks and 19.18g/day from inhalation exposure group III, respectively. The highest lung and liver weight were 1.27g and 8.19g from inhalation exposure group II, respectively. The highest kidney weight was 1.805g from inhalation exposure control. The lowest cadmium content in lung was 86.39μg/g from inhalation exposure group III. The lowest cadmium concentration in blood was 7.12㎍/㎗ from inhalation exposure group III. Cadmium concentrations of 40.02㎍/g in liver and 69.18㎍/g in kidney were the lowest from inhalation exposure group I and III, respectively. For weekly cadmium concentration in urine, the value of the fourth week from inhalation exposure group III was the highest, 3.12㎍/㎖. For weekly cadmium concentration in feces, the value of the fourth week from inhalation exposure group III was the highest, 2.67 ㎍/g. The highest metallothionein concentration in lung was 74.65㎍/g from inhalation exposure group III and the highest metallothionein concentration in liver was 386.84㎍/g from inhalation exposure group II. The highest metallothionein concentration in kidney was 236.17 ㎍/g from inhalation exposure group II.

Keywords

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