Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Study on the Effect of Benincasae Semen on Cultured Mouse Myocardial Cells Damaged by Adriamycin

Adiamycin에 의해 손상된 심근세포에 대한 동과의 영향에 관한 연구

  • Hong Gi Youn (School of Medicine, Wonkwang University) ;
  • Lee Young Mi (School of Medicine, Wonkwang University) ;
  • Lee Jung Hun (School of Medicine, Wonkwang University) ;
  • Lee Kang Chang (Graduate School of Oriental Medicine, Wonkwang University) ;
  • Cho Hae Won (College of Dental Medicine, Wonkwang University) ;
  • Han Kyung Su (College of Dental Medicine, Wonkwang University)
  • Published : 2002.12.01
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Abstract

To examine the cardiotoxic effect of adriamycin on cultured rat myocardial cells, cytotoxicity was measured by MTT assay after cultured myocardial cells were grown with various concentrations of adriamycin(ADA) for 48 hours. The protective effect of Benincasae Semen(BS) on ADR-induced cardiotoxicity was also examined in these cultures. ADR decreased cell viability of cultured rat myocardial cells remarkably in a dose- and time-dependent manners. In protective effect of BS, it was very effective in blocking ADR-induced cytotoxicity. From these results, it is suggested that ADR shows cardioxicity, and the herba extract, as is very effective in preventing ADR-induced cytotoxicity on cultured rat myocardial cells.

Keywords

References

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